TL;DR
Results indicate that decreased Aβ42 in NE-depleted mice stems not from altered DA but from NE loss, highlighting the NE-mediated regulation of endogenous Aβ42 and the role of NE in AD-related pathology.
The locus coeruleus (LC), the brain’s principal source of norepinephrine, critically regulates cognitive function. While our previous work established that prenatal lipopolysaccharide (LPS) exposure causes cognitive deficits in rat offspring, the underlying mechanisms and potential therapeutic targets remained unknow...
Stress is a major risk factor for depression- and anxiety-related disorders and produces neuroplastic adaptations within brain regions that regulate emotion, cognition, and stress responsivity. These adaptations include dendritic retraction in the medial prefrontal cortex (mPFC), suppression of plasticity and neurogene...
Dysregulation of the noradrenergic system has been implicated in the pathophysiology of schizophrenia. Although α2-adenergic receptor (α2-AR) agonists may alleviate positive symptoms, their effects on cognitive and negative symptoms remain controversial. This study aimed to characterize the dose-dependent effects of re...
MPTP-induced PD is accompanied by HPA axis overactivation and downregulation of microglial GR signaling, suggesting that this pathway contributes to MPTP neurotoxicity.
3,4-dihydroxyphenethylamine, commonly known as dopamine (DA), is a neuromodulator that fine-tunes neuronal excitability, neurotransmitter release, and the effects of other neurotransmitters on postsynaptic neurons. DA, acting on D1 and D2 receptor families, is involved in myriad functions. In the striatum, it is mainly...
Parkinson's disease (PD) is characterized by progressive nigrostriatal degeneration, dopamine depletion, and interactions among neuronal vulnerability, oxidative imbalance, and neuroinflammatory responses. AA-2βG is a chemically stable ascorbate derivative; however, its protective profile in experimental parkinsonism r...
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