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EIF4A3-dependent nonsense-mediated decay buffers AML1-ETO9a dosage and modulates outcome in t(8;21) acute myeloid leukemia

Min Zhang Yisheng Li Bin Zhang Chen Cai Shuyi Li Zhijie He Xiangyu Meng Chengguang Wang Wei-Chao Ding Xiao-Qi Wang Xingli Dong Yong-Hui Li Li Yu
Jul 2026 · Leukemia · Vol 40, pp. 1985 - 1996 · 1 citation · 34 references
Medicine

TL;DR

EIF4A3-dependent NMD is defined as a checkpoint linking RNA surveillance to oncogenic fusion-isoform dosage, leukemic fitness, and chemosensitivity in t(8;21) AML, providing a mechanistic explanation for clinical heterogeneity in t(8;21) AML.

DOI PubMed Semantic Scholar
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