2026· [Rinsho ketsueki] The Japanese journal of clinical hematology· Vol 67 7, pp.
819-827
· 0 citations
Medicine
TL;DR
Emerging strategies to ameliorate GVHD without attenuating GVL, including intensified local therapy, selective trafficking blockade, S1PR modulators that limit pathogenic T-cell migration, and tissue-protective agents that enhance epithelial regeneration and prevent the establishment of inflammatory memory are summarized.
A GVL Failure Framework is proposed that organizes posttransplant relapse into three biologically defined categories of immune escape, aligns matched cellular therapies with each, and overlays a separate clinical transplant-eligibility axis that sets the therapeutic goal.
Naif I. Aljohani, Ahlam Almasari, Zayed Alzahrani et al.· Frontiers in Immunology· 0 citations
The mechanism whereby immunotherapy with Tregs/Tcons protects from GvHD while it preserves GvL in murine transplantation models and in transplanted leukemia patients is shown for the first time.
L. Ruggeri, Antonio Pierini, E. Urbani et al.· Blood Advances· 0 citations
A review of the current concepts of post-transplant maintenance therapy in AML/MDS discusses emerging evidence supporting MRD-guided treatment strategies and molecularly targeted maintenance approaches, highlighting future perspectives for optimizing relapse prevention after allo-HSCT.
Y. Najima· [Rinsho ketsueki] The Japane...· 0 citations
The use of venetoclax-based regimens, FLT3 inhibitors, and IDH inhibitors has improved treatment outcomes by enabling the achievement of measurable residual disease (MRD)-negative remission, highlighting the importance of maintenance strategies using azacitidine and FLT3 inhibitors, as well as MRD-guided preemptive int...
Y. Najima· [Rinsho ketsueki] The Japane...· 0 citations
A focused Perspective asks whether GvHD directed engineering has made clinically significant product-associated GvHD rare and whether allogeneic CAR-T must reduce donor-to-host alloreactivity while managing the distinct host-versus-graft barrier.
Nabeel Ahmed, Jawaria Jabeen· Transplantation and Cellular...· 0 citations
This review critically reviews the molecular signatures and protective mechanisms of relapse-initiating cells and introduces innovative CAR T cell engineering strategies that are aimed at disrupting the bone marrow niche, eliminating malignant stemness, overcoming exhaustion of engineered T cells and redefining the the...
A. Mathew, Ronak Raheja, Pranav Thomas Alex· International Immunopharmaco...· 0 citations
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