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Predicting Craniospinal Surgery in Pediatric Achondroplasia: Benchmarking Statistical Inference and Explainable AI Under Rare-Disease Constraints.

S. Gholampour Jesse Huang Dylan S. Keusch Carolina Lopes Aseel Masarwy J. Obayashi M. Ruppert-Gomez Christina M. Sayama Lissa C. Baird M. Danielpour David F. Bauer
Sep 2026 · Annals of Biomedical Engineering · 0 citations · 47 references
Medicine

TL;DR

In a reproducible dual-stream benchmark, XAI improved discrimination over conventional inference by capturing clinically contextualized, complex nonlinear predictive dependencies and interactions associated with cranial and spinal surgical risk in achondroplasia using preoperative variables.

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