Sep 2026· Zenodo (CERN European Organization for Nuclear Research)
Abstract
Superseded. This record is retired and should not be used or cited. It is replaced by 10.5281/zenodo.22234051, which is the archive accompanying the manuscript. Version v2.0.0 of this record (10.5281/zenodo.22232689) additionally contained files that should not have been distributed and its removal has been requested. Analysis pipeline for a retrospective cohort study of cumulative intraoperative hypothermic burden, intraoperative red cell transfusion, and estimated blood loss in 2,567 adults undergoing non-cardiac surgery, using the open VitalDB perioperative database. Scripts run in numeric order: 01-14 reproduce the originally submitted analysis, and 15-23 produce the first revision, including the edge-trimmed thermal exposure metric, threshold and dose analyses, and the table and figure builders. The repository carries code only; the manuscript, cover letters and peer-review correspondence are not distributed. VitalDB source data are openly available at https://vitaldb.net and are not redistributed here. v2.2.0 is the clean release accompanying the first revision submitted to BMC Anesthesiology. The repository was rebuilt from a single commit containing code only. Key methodological change from v1.1.0: core temperature had been integrated across the whole anaesthesia window, which counts probe equilibration at insertion and probe withdrawal at emergence as hypothermia, implying an implausible cohort nadir of 33.30 °C. Exposures are now computed after excluding the first and last 5 minutes of each case's monitored window. Cumulative burden is essentially unchanged (Pearson r=1.00, Spearman rho=0.99); the nadir corrects to 35.04 °C. Earlier v2.x versions are superseded. v2.0.0 in particular should not be used.
Agile - denoting "the quality of being agile, readiness for motion, nimbleness, activity, dexterity in motion" - software development methods are attempting to offer an answer to the eager business community asking for lighter weight along with faster and nimbler software development processes. This is especially the case with the rapidly growing and volatile Internet software industry as well as for the emerging mobile application environment. The new agile methods have evoked substantial amount of literature and debates. However, academic research on the subject is still scarce, as most of existing publications are written by practitioners or consultants. The aim of this publication is to begin filling this gap by systematically reviewing the existing literature on agile software development methodologies. This publication has three purposes. First, it proposes a definition and a classification of agile software development approaches. Second, it analyses ten software development methods that can be characterized as being "agile" against the defined criterion. Third, it compares these methods and highlights their similarities and differences. Based on this analysis, future research needs are identified and discussed.
P. Abrahamsson, O. Salo, Jussi Ronkainen et al.· arXiv.org· 728 citations· ⚡54
Context: Software startups are newly created companies with no operating history and fast in producing cutting-edge technologies. These companies develop software under highly uncertain conditions, tackling fast-growing markets under severe lack of resources. Therefore, software startups present a unique combination of characteristics which pose several challenges to software development activities. Objective: This study aims to structure and analyze the literature on software development in startup companies, determining thereby the potential for technology transfer and identifying software development work practices reported by practitioners and researchers. Method: We conducted a systematic mapping study, developing a classification schema, ranking the selected primary studies according their rigor and relevance, and analyzing reported software development work practices in startups. Results: A total of 43 primary studies were identified and mapped, synthesizing the available evidence on software development in startups. Only 16 studies are entirely dedicated to software development in startups, of which 10 result in a weak contribution (advice and implications (6); lesson learned (3); tool (1)). Nineteen studies focus on managerial and organizational factors. Moreover, only 9 studies exhibit high scientific rigor and relevance. From the reviewed primary studies, 213 software engineering work practices were extracted, categorized and analyzed. Conclusion: This mapping study provides the first systematic exploration of the state-of-art on software startup research. The existing body of knowledge is limited to a few high quality studies. Furthermore, the results indicate that software engineering work practices are chosen opportunistically, adapted and configured to provide value under the constrains imposed by the startup context.
Nicolò Paternoster, Carmine Giardino, M. Unterkalmsteiner et al.· Information and Software Tec...· 394 citations· ⚡54
What if pathology foundation models could do more with less? GigaPath-Flash and GigaTIME-Flash cut computational demands while maintaining strong performance, opening the door to larger studies and broader exploration. The post GigaPath-Flash and GigaTIME-Flash: Toward population-scale discovery with efficient pathology foundation models appeared first on Microsoft Research.
MIT News · Artificial Intelligence· news.mit.eduAug 31, 2026
With millions of users across the world, Julia has been used to conduct cutting-edge research and to design new drugs, jet engines, heat pumps, and more.
MIT News · Artificial Intelligence· news.mit.eduAug 27, 2026
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
