A two-stage framework separating symptom-candidate generation from definition-grounded verification of depression symptoms is proposed, which support decomposing symptom recognition into candidate generation and definition-grounded verification, though performance remains limited for rare categories.
Abstract
Sentence-level recognition of depression symptoms is challenging because similar expressions can differ in symptom relevance, and language-model inference is insufficiently grounded in diagnostic definitions. This study proposes a two-stage framework separating symptom-candidate generation from definition-grounded verification. A contrastively fine-tuned sentence encoder generates a symptom candidate per sentence, and a fine-tuned language model verifies whether the candidate is present or absent using the sentence, its context, and a candidate-specific diagnostic definition, checking its judgment against that definition before answering. Evaluated against encoder, inference-based, medical, and general LLM baselines and a matched single-stage supervised classifier, the proposed pipeline attains the best accuracy and F1 scores of all methods, with rationales matching expert-authored annotations. A preliminary clinical audit indicates moderate alignment with diagnostic definitions, with explanation quality strongly dependent on prediction correctness. The results support decomposing symptom recognition into candidate generation and definition-grounded verification, though performance remains limited for rare categories.
Early depression detection from textual narratives has advanced substantially with transformer-based language models and Large Language Models (LLMs). However, reliable screening-oriented decision support requires more than high predictive accuracy. Existing approaches often lack explicit symptom-level grounding, produ...
Firas Saidi, Marwa Almulla· Frontiers in Artificial Inte...· 0 citations
These results identify the answer-token boundary, rather than semantic representation alone, as a measurable source of error in this benchmark, and introduce heterogeneous readout decomposition (HRD), which separates semantic verification from output realization.
Biomedical large language model (LLM) evaluation requires auditable assessment of narrow, evolving, source-grounded subspecialty knowledge. Multiple sclerosis MRI (MS-MRI) provides a high-stakes textual-knowledge test case because correct reasoning requires current diagnostic criteria, standardized acquisition and repo...
Abdul Basit, M. Hanif, Muhammad Shafique· 0 citations
Depression is a widespread and frequently under-diagnosed mental health condition, and delays in identification
are associated with poorer long-term outcomes. This paper presents a hybrid screening framework that combines a validated
questionnaire to the Patient Health Questionnaire-9 (PHQ-9), with linguistic feature e...
Tanuj Chauhan, Abhishek Verma· International Journal of Inn...· 0 citations
Zero-shot LLMs substantially outperform rule-based and NER approaches for CRC symptom extraction; post-hoc negation correction should not be applied to LLM outputs without syntactic scope validation.
Y. Lee, I. Dinov, X. Hu et al.· medRxiv· 0 citations
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