Streptomyces griseoincarnatus AR2 from the cold desert as a biofactory for secondary metabolites with multifaceted bioactivities, confirmed by in vitro and in silico approaches
Aug 2026· Archives of Microbiology· Vol 208· 0 citations· 73 references
Medicine
TL;DR
Bioactive potential of deep yellow pigment and other metabolites from Streptomyces griseoincarnatus AR2, previously recovered from Katpana Cold Desert, Gilgit-Baltistan, Pakistan, is reported, manifesting complementation of multiple bioactive compounds.
This is the first report on GMPS inhibition by phenolic compounds, and the binding interaction between 11 and GMPS was primarily stabilised by two hydrogen bonds formed between the hydroxyl group in 11 and amino acid residues in GMPS.
Wen Li, Shu-Qi Li, Mei Wang et al.· Natural Product Research· 0 citations
This study investigates the activation of cryptic biosynthetic genes within this strain through chemical elicitation to amplify the production of secondary metabolites, position this strain as a valuable resource for discovering novel antimicrobials.
Madhuri Mukindrao Moon, John Godwin Christopher· BioTechnologia· 0 citations
The excellent anti-vibrio activity of 1, which is superior to chloramphenicol, is reported, and its ribosome-targeting mechanism of action is clarified.
It is highlighted that PTM-type compounds may serve as promising compounds for the further development of α-glucosidase inhibitors and lays the foundation for research on their biosynthesis.
Zhong Wang, Guangling Wu, Jian Pan et al.· BMC Genomics· 0 citations
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