Aug 2026· International Journal of Clinical Oncology· 0 citations· 25 references
Medicine
TL;DR
The efficacy of CAR T-cell therapy in patients with R/R HGBCL remains suboptimal, and high-grade morphology may help identify patients at particularly high risk of poor outcomes following CAR T-cell therapy.
The unmet needs in patients with high-risk disease and the challenges of sequencing these therapeutic strategies are discussed, while providing expert clinical practice recommendations to optimize patient outcomes are provided.
P. Caimi, Romano Danesi, G. Iacoboni et al.· Blood reviews· 0 citations
This study demonstrated superior response rate and PFS of CD19 CAR-T over platinum-based salvage with intent to proceed to HDT/ASCT as 2L treatment for R/R PMBCL.
Xi Yang, Henry Dumke, Swetha Kambhampati Thiruvengadam et al.· Blood Advances· 0 citations
Outcomes after CAR-T failure in LBCL remain poor despite the availability of multiple salvage treatment strategies, and time to relapse after CAR-T therapy was the strongest prognostic factor.
Smith Kungwankiattichai, Sanjog Bastola, Manoj Rai et al.· Transplantation and Cellular...· 0 citations
In this nonrandomized clinical trial, bicistronic CD19/CD22 CAR T-cell therapy induced high rates of minimal residual disease-negative remission, with durable EFS in pediatric B-ALL, and support further evaluation in prospective trials.
Xinyu Wan, Yan-Jing Tang, Jiao-Yang Cai et al.· JAMA Oncology· 1 citation
Background Therapy-related myeloid neoplasms (t-MNs) have emerged as a serious late complication of CD19-directed chimeric antigen receptor (CAR) T-cell therapy. While large-scale studies have characterized the epidemiology of t-MNs, the mechanisms underlying their development remain incompletely understood, and cases...
Manqi Su, Chentong Huang, Zhan-Na Zhang et al.· Frontiers in Medicine· 0 citations
This phase 1 dose-escalation part of the ATALANTA-1 phase 1/2, single-arm study was executed in five hospitals in the Netherlands and Belgium to evaluate the safety and determine the recommended phase 2 dose of GLPG5101.
M. Kersten, M. Kuipers, P. Mutsaers et al.· The Lancet Haematology· 0 citations
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