This review provides an integrated overview of emerging AV approaches targeting quorum sensing, type III secretion systems, biofilm development, adhesion, toxin activity, iron acquisition, and host-pathogen interactions and suggests that AV therapy is best positioned as a precision anti-infective strategy.
The rapid emergence and global dissemination of antimicrobial resistance (AMR), coupled with the limited development of new antimicrobial agents, have intensified concerns regarding a major global public health crisis. Although antibiotic resistance is primarily driven by microbial mechanisms, host immune and inflammat...
Sarmistha Saha, N. Sachivkina, Oksana Gizinger et al.· Frontiers in Pharmacology· 0 citations
This review synthesizes recent advances in AMP research, focusing on their structural diversity, mechanistic interactions with microbial membranes, and immunomodulatory roles in shaping host-microbe dynamics, and establishes a framework for overcoming current limitations.
Zhu-Yu Hua, Xu Xia, Khan Qaisar et al.· Frontiers in Microbiology· 0 citations
This review comprehensively examines resistance mechanisms across major microbial pathogens and discusses the evolution of nanomedicine as an advanced platform for combating AMR, highlighting the synergistic interactions between nanomaterials and conventional antimicrobial agents that enhance therapeutic efficacy and r...
Vishal L. Handa, Benedict B. Vyas, Abhishek Padhi et al.· Frontiers in Chemistry· 0 citations
This review explores how computational design, artificial intelligence, and peptidomimetics can generate next-generation AMPs with enhanced stability and reduced toxicity, framing their role in future antimicrobial strategies.
Shesham Kumari, Ranjeet Kumar, Manish Singh et al.· Current protein and peptide...· 0 citations
This review summarizes the current evidence on non-antibiotic therapeutics including bacteriophages, antimicrobial peptides, anti-virulence agents, monoclonal antibodies, microbiome-based therapies, CRISPR-Cas systems, nanoparticles, photodynamic therapy, repurposed non-antibiotic drugs and combination strategies.
Bharath Kumar Ganesan, A. Mishra, Debasish Hota et al.· Expert Review of Clinical Ph...· 0 citations
Overall, plant-derived therapeutics represent a promising and sustainable avenue for the discovery and development of complementary antimicrobial strategies to address the growing global burden of AMR.
Deeksha Rathor, Pushpendra Kumar, Km. Neha et al.· GLOBAL JOURNAL OF PHARMACEUT...· 0 citations
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