Sustainable UHPLC-MS/MS assay for ultra-sensitive simultaneous quantification of amoxicillin and flucloxacillin with application to a bioequivalence study.
Aug 2026· Analytical and Bioanalytical Chemistry· 0 citations· 43 references
Medicine
TL;DR
The developed UHPLC-MS/MS method was successfully applied in a bioequivalence study involving 33 healthy volunteers following oral administration of a single 5 mL dose of Flucamox® 250 mg, enabling comprehensive pharmacokinetic evaluation while promoting sustainable and resource-efficient analytical practices.
A sensitive and reliable ultra-high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of ibuprofen in plasma to investigate the pharmacokinetics of ibuprofen after oral administration of ibuprofen sustained-release capsules.
Mei-Ah Yang, Kui He, Yu-Jie Mo et al.· Acta Chromatographica· 0 citations
A sensitive, rapid, and robust liquid chromatography-tandem mass spectrometry method incorporating a stable isotope-labeled internal standard incorporating phloroglucinol-13C6 was developed and validated and successfully applied to a pharmacokinetic and bioequivalence study of phloroglucinol orally disintegrating table...
Qi-Qin Sun, Xiang-Hong Li, Yun-Jie Dong et al.· Journal of chromatography. B...· 0 citations
A sensitive and validated liquid chromatography-tandem mass spectrometry method was developed for the simultaneous quantification of the anti-COVID-19 agents molnupiravir, its active metabolite N-hydroxycytidine (NHC), and baricitinib in human plasma, and met the acceptance criteria.
Fatma H. Ghazy, Ramzia I. El-Bagary, Samar H. Fahim et al.· Bioanalysis· 0 citations
Objective: Nifurtimox is a type of nitrofuran derivative employed for treating sleeping sickness as well as Chagas disease. The aim is to develop and validate a precise and specific liquid chromatography mass spectrometric technique for the estimation of Nifurtimox in human plasma.Material and Method: Chromatographic s...
J. K. Bokam, Jagadeesh Adari, Ch Rama Naidu Gorripati et al.· Ankara Universitesi Eczacili...· 0 citations
The findings regarding accuracy, specificity, sensitivity, matrix effect, recovery and stability findings of Lurbinectedin in plasma samples for the established method highlight its significance in bioequivalence and pharmacokinetic studies.
P. Sankar, Naresh Panigrahi· International Journal of App...· 0 citations
