Open access

Chronic Hypoxic Signalling Reprograms Metabolism and Alters Redox and Lipid Homeostasis in Rod Photoreceptors

Larissa P. Govers Daniel T. Hass M. Agbaga C. Matter Antonia Fottner M. Samardzija James B. Hurley Christian Grimm

Jul 2026 · bioRxiv · 0 citations · 12 references

Biology

TL;DR

Outdoor segment lipidomics revealed selective remodelling of phosphatidylcholine and phosphatidylethanolamine species toward more oxidation-resistant and elongated acyl chains, supported by early gene upregulation of essential enzymes involved in fatty acid elongation, desaturation and oxidation.

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