Can baxdrostat redefine blood pressure control in resistant and uncontrolled hypertension? a systematic review, meta-analysis, and trial sequential analysis.
Jul 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 1 citation· 18 references
Medicine
TL;DR
Baxdrostat, particularly at 2 mg, provides clinically meaningful BP reductions, and serious safety outcomes remain entirely comparable to control, which highlights a reassuring safety profile.
Baxdrostat lowers blood pressure and aldosterone levels in uncontrolled and resistant hypertension but increases potassium and modestly reduces eGFR, supporting careful laboratory monitoring and longer trials to evaluate long-term clinical outcomes.
A. Gadelmawla, A. Hageen, R. Rateb et al.· Cardiology in Review· 0 citations
Findings strengthen the evidence for selective aldosterone synthase inhibition as a therapeutic approach for aldosterone-mediated hypertension and suggest that baxdrostat may provide an additional treatment option, particularly for patients who remain uncontrolled or cannot tolerate mineralocorticoid receptor antagonis...
Muhammad Burhan, Z. Shahid, M. Naveed et al.· The Annals of Pharmacotherap...· 0 citations
Baxdrostat 1 mg and 2 mg significantly increased overall adverse events and hyperkalemia, whereas serious adverse events were not significantly increased, and both higher doses significantly increased hyperkalemia risk.
M. Shahzaib, Hafsa Ali, Muhammad Roshaan et al.· Naunyn-Schmiedeberg's Archiv...· 0 citations
Overall, zilebesiran produced significant and consistent BP reductions, especially in ambulatory measures, with a favorable safety profile, and builds on previous meta-analyses that included only 2 RCTs; this updated analysis reflects the need for novel therapeutic options.
Muhammad Hussain, Muhammad Hassan, Asharib Sohaib et al.· European Journal of Clinical...· 1 citation
SGLT-2 inhibitors provide a modest incremental benefit in lowering office systolic blood pressure for patients with uncontrolled or resistant hypertension on multidrug regimens with an overall acceptable safety profile.
Omer Mohammed, Sun Hyeok Kim, A. Karthikeyan et al.· High Blood Pressure & Cardio...· 0 citations
Selective aldosterone synthase inhibitors (ASIs), including baxdrostat and lorundrostat, target CYP11B2 while sparing cortisol synthesis, offering a novel strategy for resistant and uncontrolled hypertension. Yet existing meta-analyses have included nonselective agents or omitted the latest phase 3 data. We searched Pu...
N. Hammad, M. Elkasaby, A. Gadelmawla et al.· Cardiology in Review· 1 citation
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