TL;DR
The results suggest that the crude epidemiologic association between blood lead and CRC prevalence is sensitive to covariate adjustment and generate testable hypotheses implicating HMOX1 for future experimental validation.
These findings identify CDC20 as a recurrence-associated molecular node involved in BaP-responsive malignant biological phenotypes and provide a phenotype-anchored framework linking recurrence biology with environmental exposure-related tumor behavior.
Background and objectives Wilms tumor, a common childhood malignancy, has been hypothesized to be associated with environmental factors such as formaldehyde exposure. As a potential endocrine disruptor with reported pro-proliferative effects, the molecular mechanism underlying the role of formaldehyde in Wilms tumor re...
Convergent genetic, transcriptomic, and protein-level evidence prioritizes CDC16 as a GC-associated candidate tissue marker whose expression is closely linked to proliferative activity.
This study provides a systematic multi-omics characterization of immune microenvironment remodelling in CRC and identifies candidate molecular regulators that may serve as potential targets for future immunotherapy research.
BPA-induced CXCL8 upregulation is associated with CRC malignant progression and enhanced p38 MAPK signaling, and TEAD4 may function as an upstream transcriptional regulator of CXCL8, although its direct regulation by BPA remains unclear.
Immune checkpoint inhibitors are used to treat head and neck cancer (HNC), but clinical responses vary, and systematic genetic evaluation is needed to prioritize candidate susceptibility genes. We applied summary-data-based Mendelian randomization (SMR) and HEIDI testing to screen 624 immune checkpoint–related genes, i...
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