Aug 2026· Neurological Sciences· Vol 47· 0 citations· 31 references
Medicine
TL;DR
A BBB permeability-related score is associated with longitudinal progression from mild cognitive impairment to clinically diagnosed AD dementia; CD226 is a biologically supported candidate signal; GFRα-1 is hypothesis-generating pending replication.
Higher CSF neuroinflammatory biomarkers may be linked to AD pathology and cognitive impairment; however, given the observational design, causality cannot be established, and longitudinal mechanistic studies are needed to validate these findings.
Mubarak Alruwaili, A. Turkistani, S. Shilbayeh et al.· Immunologic research· 0 citations
Elevated NLR was significantly and independently associated with accelerated decline across multiple cognitive domains and an increased risk of clinical progression in older adults at risk for AD and a potential role for peripheral immune dysregulation in early disease trajectories is observed.
Xin Wang, Xiao-Lei Liu, Zhi-Gang Wang et al.· Frontiers in Aging Neuroscie...· 0 citations
CSF tTau was associated with mortality and faster clinical progression, but the joint-model findings involving tTau and pTau should be interpreted cautiously as hypothesis-generating.
Aslı Aksoy Gündoğdu, B. Samancı, M. Alaylıoğlu et al.· Journal of Alzheimer's Disea...· 0 citations
A link between systemic inflammatory burden and hippocampal vulnerability is supported, while relationships with AD pathology and clinical progression warrant further investigation.
Hong-Sheng Xie, Yu-Hao Li, Ruo-Qiu Gan et al.· Progress in Neuro-psychophar...· 0 citations
Findings identify complement dysregulation, especially involving C1q, as an early correlate of tau-linked synaptic pathology, and support a role for complement activation in the AD molecular cascade.
J. Loncke, M. Savard, C. Picard et al.· bioRxiv· 0 citations
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