Aug 2026· World journal of urology· Vol 44· 0 citations· 39 references
Medicine
TL;DR
This Mendelian randomization study revealed suggestive genetically predicted associations between 29 plasma proteins and bladder cancer risk, and implied that plasma lipidomic traits may partially mediate a subset of these relationships.
Abstract The causes of most cancers remain unknown because the biological pathways underlying cancer development are poorly understood. Large-scale plasma proteomics offers a powerful strategy to uncover these pathways, identify biomarkers for cancer early detection, and discover novel therapeutic targets but has rarel...
J. Yarmolinsky, V. Viallon, V. Burk et al.· medRxiv· 0 citations
Genetically proxied plasma RARRES1 is associated with increased LCINS risk and may contribute to disease susceptibility through immune-related alterations involving NKT-cell phenotypes, providing biologically plausible evidence supporting a role for RARRES1 in LCINS pathogenesis and its potential utility in biomarker d...
Jian-Cong Wu, Qi Zhang, Yan-Ming Lin et al.· Current Medicinal Chemistry· 0 citations
These findings delineate the first causal blueprint of the OP plasma proteome, and NUDT2 is highlighted as a plausible metabolic regulator of bone formation and accelerates the development of novel therapeutics for osteoporosis.
Zhen Wang, Si-Xu Chen, Junjie Luo et al.· Journal of Advanced Research· 0 citations
This study identified PARP1, SDCCAG8, FST, FOLH1, and NCAN as genetically prioritized candidate proteins for CA, with PARP1 showing the most consistent evidence across analyses.
Da Gao, Hai-Yan Lin, Sheng-Jie Wang et al.· Cardiovascular Therapeutics· 0 citations
Plasma lipid composition has been linked to multiple cancers, yet its causal contribution to gastric cancer and the potential intermediary role of immune cells remain unclear. We aimed to clarify these relationships and identify specific lipid and immune cell traits that either protect against or promote gastric cancer...
Peng Huang, Tian-Qi Yu, Lei Wang et al.· Medicine· 0 citations
Background: Esophageal adenocarcinoma (EAC) is a complex disease often preceded by Barrett's esophagus. Objective: This study aimed to identify potential drug targets and support early prevention and treatment. Method: We integrated cis-protein quantitative trait loci (cis-pQTLs) and genome-wide association study (GWAS...