Enhanced antibacterial and anti-biofilm activity of PEGylated niosomes co-loaded with nisin and ZnO nanoparticles against VRSA and ceftazidime-resistant Pseudomonas aeruginosa
PEGylated niosomal co-delivery of Nis and ZnO nanoparticles provides a potent, broad-spectrum, and biocompatible strategy to combat multidrug-resistant bacteria and disrupt biofilms, supporting its potential for further in vivo evaluation.
These proof-of-concept findings indicate that C. verum-mediated Fe₂O₃-NPs show potent in vitro multi-mechanism antibacterial activity against two clinically confirmed CRE UPEC isolates, combining promising antibacterial potency with transcriptional suppression of key virulence determinants.
Ahmed Abass Fadel, K. H. Alobaidi, J. Al-Obaidi· International Microbiology· 0 citations
Methicillin-resistant Staphylococcus aureus (MRSA) infections remain a major public health challenge because of limited therapeutic options and the increasing prevalence of multidrug resistance. In this study, carrier-free quercetin-zinc supramolecular assemblies (Qct-Zn NPs) were fabricated through coordination-associ...
Ying Chen, Xiu-Zhen Chen, Wei-Xiao Wang et al.· Frontiers in Microbiology· 0 citations
Urinary tract infections (UTIs) caused by Gram-negative bacteria such as E. coli, P. aeruginosa and P. mirabilis are a serious health concern due to their ability to establish biofilm and antibitotic resistance. Niosomes loaded with nisin were formulated and analyzed in this study to evaluate their potential as a new n...
Shahad Jamal Rashed, Ammar R. Algburi, Razieh Niazmand et al.· Diyala Journal for Veterinar...· 0 citations
Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated mortality, with multidrug resistance and biofilm formation limiting treatment options. Anti-virulence strategies targeting adhesin gene expression offer a promising alternative, yet the ability of green-synthesised ZnO-NPs to s...
Aws Nasser, K. H. Alobaidi, J. Al-Obaidi· International Microbiology· 0 citations
Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a major therapeutic challenge due to antimicrobial resistance and biofilm formation. This study developed chitosan-coated meropenem-loaded niosomes (Nio-MRP@CS) and evaluated their physicochemical properties and antibacterial, antibiofilm, and gene-modulating acti...
F. Ashrafi, G. Khalili, P. Moulavi et al.· Journal of Microencapsulatio...· 0 citations
Background: Biofilms formed by Staphylococcus aureus display marked tolerance to conventional antibiotic therapy, which contributes to the persistence of chronic infections and complicates their clinical management. There is therefore a pressing need to develop alternative delivery strategies capable of penetrating the...
Kamalesh Pandidurai, Baby Roselin Rajandurai, Justin Anthony et al.· Biomedical Engineering Commu...· 0 citations
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