Precision repurposing of clinically characterized molecules targeting dengue virus RNA-dependent RNA polymerase: an in silico identification and in vitro validation.
Proanthocyanidin is identified as a promising RdRp-targeting antiviral candidate and the value of integrating computational and experimental approaches for dengue drug discovery is demonstrated, demonstrating the value of integrating computational and experimental approaches for dengue drug discovery.
The conserved hydrophobic pocket at the dimer interface of the dengue capsid protein is explored as a novel target for antiviral intervention and repurposing of small molecules as anti-dengue therapeutics is proposed.
Dwaipayan Chaudhuri, K. Giri· In Silico Pharmacology· 0 citations
Influenza, an acute respiratory infectious disease caused by influenza viruses, poses a serious public health threat with high infectivity and virulence. Existing antivirals suffer from numerous limitations, such as the frequent emergence of drug resistance and inconvenient administration, highlighting the urgent need...
Xinru Zhang, Heng Jia, Xianglong Wang et al.· ACS Infectious Diseases· 0 citations
The findings discussed in this review underscore the promise of eco-friendly nanotechnology as a sustainable and effective platform for developing next-generation antiviral therapies against dengue virus.
D. M. Kumar, R. Bharath, P. Venkataraman et al.· Viruses· 0 citations
This review examines the principles and applications of target-based antiviral drug development against human respiratory viruses, emphasizing the identification and exploitation of conserved viral and host targets.
S. K. Samrat, Gaurie Srivastava, Ran Zhang et al.· Pathogens· 0 citations
A comprehensive overview of the detailed structural information of the viral protease (NS2B/NS3) enzyme with the mechanistic role of this enzyme, and various inhibitors related to the NS2B/NS3 protease are highlighted.
This narrative review critically analyses the principal molecular targets of DENV, including structural proteins (C, prM/M and E), nonstructural proteins (NS1–NS5) and host factors, with emphasis on the development of small‐molecule antivirals and an evaluation of their progress in pre‐clinical and clinical studies.
Aryane Lucia da Silva Aguiar De Oliveira, José Arion da Silva Moura, Pedro César de Souza et al.· ChemistrySelect· 0 citations
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