Biofilm disruption by citronellol and geraniol against clinical uropathogenic Pseudomonas aeruginosa: an integrated in vitro and in silico investigation

Asma Benaissa A. N. Tamfu Waffa Bouali Ammara Bousselham Houria Medjdoub Brahim Babali Arslan Eroglu Busra Selcuk Kucukaydin E. Anouar Ozgur Ceylan

Jul 2026 · Molecular Biology Reports · Vol 53 · 0 citations · 58 references

Medicine

TL;DR

P. graveolens EO, citronellol, and geraniol exhibited promising anti-virulence properties against multidrug-resistant uropathogenic P. aeruginosa, supporting their potential as complementary agents for controlling biofilm- and motility-associated infections.

DOI PubMed Semantic Scholar

View source

Similar papers

Aug 2026

Integrated in Vitro and in Silico Investigation of Antimicrobial, Anti-biofilm, and Quorum-Sensing Inhibitory Activities of Allium atroviolaceum Bulb Extract

Overall, the findings indicate that EAABE exhibits promising in vitro antimicrobial and anti-virulence activities; however, further isolation of individual constituents, experimental validation, and mechanistic investigations are needed to clarify the specific contribution of each metabolite to the observed effects.

K. Alabbosh, M. Snoussi, M. Alzahrani et al. · Applied Biochemistry and Bio... · 0 citations

Open access Sep 2026

In Vitro antibacterial, anti-biofilm, and virulence-modulating activity of Cinnamomum verum-mediated iron oxide nanoparticles against carbapenem-resistant uropathogenic Escherichia coli.

These proof-of-concept findings indicate that C. verum-mediated Fe₂O₃-NPs show potent in vitro multi-mechanism antibacterial activity against two clinically confirmed CRE UPEC isolates, combining promising antibacterial potency with transcriptional suppression of key virulence determinants.

Ahmed Abass Fadel, K. H. Alobaidi, J. Al-Obaidi · International Microbiology · 0 citations

Sep 2026

Synergistic effects of luteolin and Lactobacillus rhamnosus on methicillin-resistant Staphylococcus aureus biofilm inhibition: in vitro and in silico molecular deployment studies.

Results demonstrate that luteolin combined with L. rhamnosus bacterial suspension natant represents a promising natural therapeutic strategy for controlling MRSA infections by simultaneously targeting bacterial growth, biofilm formation, and virulence while maintaining acceptable biocompatibility.

S. Başer, Demet Çelebi, Ozgur Celebi et al. · Folia Microbiologica (Prague... · 0 citations

Sep 2026

Phytochemical Profiling and Antibiofilm Efficacy of Myrtus communis Extract Against Multidrug-Resistant Pathogens: A Sustainable Biotherapeutic Approach Aligned with Circular Economy Principles

It is demonstrated that methanolic leaf extract of Myrtus communis possesses considerable antibacterial and antibiofilm activities against clinically relevant MDR bacteria, supporting its potential as a natural source for developing alternative antimicrobial strategies.

Methaq Abbas · Journal of Health and Biolog... · 0 citations

Open access Sep 2026

Plant Monoterpenes Geraniol, Eugenol and Carvacrol Against Multidrug-Resistant ESKAPE Isolates from Surgical Wounds

Objectives: The study determined antimicrobial resistance profiles of surgical wound multidrug-resistant (MDR) isolates belonging to the ESKAPE group and evaluated antibacterial and antibiofilm activities of geraniol (G), carvacrol (C) and eugenol (E), individually and in the selected mixtures. The cytotoxicity of mono...

Marija Radovanović, Stanislava Čukić, Jelena Filipović Tričković et al. · Antibiotics · 0 citations

Open access Sep 2026

Enhanced antimicrobial and antibiofilm effects of Baccaurea ramiflora Lour. fruit extract combined with FMSP-nanoparticles against multidrug-resistant bacteria: an in vitro and in silico analysis

The increasing prevalence of antimicrobial resistance (AMR) and biofilm-associated infections poses significant challenges to public health. This study investigated the antibacterial and antibiofilm potential of ethanol extracts of Baccaurea ramiflora Lour. (B. ramiflora) peel (BRP) and seed (BRS) extract, combined wit...

Tripti Paul, Saad Ahmed Sami, Ashik Mosaddik et al. · Clinical Phytoscience · 0 citations