Dual therapeutic potential of bacteriocin Basin from Bacillus halophilus: attenuation of Enterococcus faecalis virulence gene expression and cytotoxic activity against KB (HeLa-Derived) cells
Bacteriocin Basin exhibits dual bioactivity by attenuating key virulence pathways in E. faecalis and exerting cytotoxic and anti-inflammatory effects on KB (HeLa-derived) cells, providing a preliminary in vitro foundation for exploring the dual bioactivity of bacteriocin Basin.
Enterococcus
species are ubiquitous members of the human microbiota, but their potential to act as opportunistic pathogens requires careful, strain-specific safety assessment. This study characterized
Enterococcus faecium
ED22 using a polyphasic approach combining whole-genome sequencing (WGS) with in vitro phen...
Ibtissame Khalid, Fatima Zahra Lafdil, A. Sellam et al.· Scientific Reports· 0 citations
Cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae increasingly limit therapeutic options, necessitating novel antimicrobial strategies. This study investigated the antibacterial and immunomodulatory potential of a bioactive Streptomyces isolate (SGM-12) and its silver nanoparticle (AgNP) formulations u...
Mohammed Alissa· Microbial Pathogenesis· 0 citations
PAM3-2 is a proteinaceous bacteriocin-like antibacterial substance produced by marine-derived A. pittii with high physicochemical stability, and exhibits broad-spectrum antibacterial activity, particularly against S. Paratyphi B, and its antibacterial effect is associated with disruption of membrane integrity.
Yi-Jun Zhen, Yi Ma, Yun-Er Long et al.· Annals of Microbiology· 0 citations
Multidrug-resistant avian pathogenic Escherichia coli (MDR-APEC) causes critically high first-week mortality in chickens, resulting in substantial economic losses in the global poultry industry. This study aimed to isolate and characterize a novel bacteriophage as an effective safe alternative for the control of coliba...
Siwaporn Bilhman, Supakit Paosen, A. Limsatanun et al.· Poultry Science· 0 citations
Antimicrobial resistance creates an urgent need for new antibacterial strategies, and medicinal plants remain an important source of chemically diverse bioactive metabolites. This study investigated the antibacterial potential of Arctium lappa L. (greater burdock) naturalized in the United States using a genome-guided...
Danae Kala Rodriguez Bardaji, Gabriella Fedus, Samantha Tran et al.· Frontiers in Pharmacology· 0 citations
BACKGROUND
The global rise of antimicrobial resistance, particularly among carbapenem-resistant Klebsiella pneumoniae (CRKP), presents a serious therapeutic challenge. This study aimed to isolate and characterize a bacteriophage effective against prophage-free CRKP and to evaluate its potential synergistic effects with...
Parva Farmehr, Salehe Sabouri, Roya Ahmadrajabi et al.· Infection & Chemotherapy· 1 citation
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