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Open access Aug 2026

Serum neurofilament light chain as a biomarker of inflammatory activity in relapsing-remitting multiple sclerosis: a real-world longitudinal cohort study

Abstract Objectives Serum neurofilament light chain (sNfL) reflects neuroaxonal injury in relapsing-remitting multiple sclerosis (RRMS), but its clinical utility is limited by high interindividual variability and confounders such as renal function. Population-based thresholds may therefore be suboptimal for longitudina...

S. de las Heras Flórez, Gema García de la Rosa, Vicente Martín García et al. · 1 citation
Review Open access Aug 2026

EP1029 - ECE_1026 - Serum neurofilament light chain: a candidate biomarker of neuroaxonal injury in patients with dysnatremia, associated with functional outcomes and mortality

High sNfL levels were associated with worse cognitive performance and muscle strength, independent of sodium levels and other potential confounders, and could serve as a novel biomarker of neuroaxonal injury in patients with hyponatremia, correlated with functional outcomes and mortality.

F. Bioletto, D. Cuboni, E. Varaldo et al. · 0 citations
Open access Aug 2026

Cerebrospinal Fluid Biomarkers of Neuroinflammation and Neuroplasticity in Type 2 Diabetes Mellitus: Association with Cognitive Performance

Background: Type 2 Diabetes Mellitus (T2DM) is associated with cognitive decline, potentially mediated by neuroinflammatory processes and altered neuroplasticity. This study investigated cerebrospinal fluid (CSF) biomarkers of neuroinflammation and neuroplasticity in T2DM individuals versus controls, and their relation...

C. M. Baracaldo Barrera, M. C. Jiménez Martínez, Sandra Rojas Vega · 0 citations
Open access Aug 2026

Correlation between the reduction of IL-6 and TNF-α with muscle mass restoration in hyperthyroid patients post-radioactive iodine therapy

IL-6 and TNF-α were associated with poorer skeletal muscle status at baseline in patients with Graves’ hyperthyroidism, but their longitudinal changes did not independently predict SMI recovery after RAI therapy.

Yuqian Ren, Cui-Juan Zheng, Meng Wang et al. · 0 citations
Open access Sep 2026

Plasma neurofilament light chain in type 2 diabetes: Associations with diabetic peripheral neuropathy, age, and renal function in a pilot cross-sectional study

Plasma NfL concentrations were higher in patients with DPN in unadjusted analyses, but the association was attenuated after accounting for age and renal function, highlighting the importance of considering age and renal function when interpreting circulating NfL concentrations in T2DM.

M. Škorvanová, A. I. Verešpejová, J. Hanes et al. · 0 citations

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