Abstract Objectives Serum neurofilament light chain (sNfL) reflects neuroaxonal injury in relapsing-remitting multiple sclerosis (RRMS), but its clinical utility is limited by high interindividual variability and confounders such as renal function. Population-based thresholds may therefore be suboptimal for longitudina...
S. de las Heras Flórez, Gema García de la Rosa, Vicente Martín García et al.· Clinical Chemistry and Labor...· 1 citation
High sNfL levels were associated with worse cognitive performance and muscle strength, independent of sodium levels and other potential confounders, and could serve as a novel biomarker of neuroaxonal injury in patients with hyponatremia, correlated with functional outcomes and mortality.
F. Bioletto, D. Cuboni, E. Varaldo et al.· European Journal of Endocrin...· 0 citations
Background: Type 2 Diabetes Mellitus (T2DM) is associated with cognitive decline, potentially mediated by neuroinflammatory processes and altered neuroplasticity. This study investigated cerebrospinal fluid (CSF) biomarkers of neuroinflammation and neuroplasticity in T2DM individuals versus controls, and their relation...
C. M. Baracaldo Barrera, M. C. Jiménez Martínez, Sandra Rojas Vega· Diabetology· 0 citations
Rising sNfL may precede mobility decline, highlighting sNfL as a potential indicator of functional worsening, and lower sNfL was associated with reduced daily ambulatory activity in progressive MS.
G. Joseph, Megan McCune, R. Bove et al.· Annals of Clinical and Trans...· 0 citations
IL-6 and TNF-α were associated with poorer skeletal muscle status at baseline in patients with Graves’ hyperthyroidism, but their longitudinal changes did not independently predict SMI recovery after RAI therapy.
Yuqian Ren, Cui-Juan Zheng, Meng Wang et al.· Frontiers in Endocrinology· 0 citations
Plasma NfL concentrations were higher in patients with DPN in unadjusted analyses, but the association was attenuated after accounting for age and renal function, highlighting the importance of considering age and renal function when interpreting circulating NfL concentrations in T2DM.
M. Škorvanová, A. I. Verešpejová, J. Hanes et al.· PLoS ONE· 0 citations
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