TL;DR
This review systematically summarizes current research on astrocyte involvement in PD pathology and their neuronal interaction mechanisms, further exploring their interconnections to elucidate disease pathogenesis.
These findings advocate for a paradigm shift from a neuron-centric to a glia-inclusive framework in PD research and treatment, positioning astrocytes as central players in the quest for disease-modifying therapies.
This network is interconnected, and understanding it is crucial in the creation of therapies that attempt to restore proteostasis, inhibit inflammation, and increase neurotrophic signalling to delay or prevent PD progression.
Abstract Background Chronic inflammation within the central nervous system is a defining feature of many neurological and neurodegenerative disorders, including Alzheimer’s disease (AD). Astrocytes, the most abundant glial cell population in the brain, play a pivotal role in maintaining neuronal homeostasis, synaptic s...
An integrative model in which neuroinflammation and metabolic dysfunction function not merely in parallel, but as mutually reinforcing components of a self-amplifying pathological circuit is proposed, while acknowledging that this model remains to be fully validated and that alternative causal architectures are possibl...
This review examines the molecular and cellular mechanisms through which neuroinflammation contributes to the progression of AD, with particular emphasis on microglial activation, TREM2 and soluble TREM2 (sTREM2) signaling, NLRP3 inflammasome activation, astrocyte–microglia interactions, and blood–brain barrier dysfunc...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
