CircRNA PVT1 promotes migration, invasion and glucose metabolism of thyroid cancer cells through modulating the miR-195-5p-PDK4 axis

The circMTCL1/miR-145-5p/BMP3 axis suppresses colorectal cancer cell growth by mediating the MAPK signaling pathway

Exosomal miR-145-5p inhibits papillary thyroid cancer by targeting TPM3 and inactivating the PI3K-Akt pathway

Within the present study, the objective was to investigate the effects of exosomal miR-145-5p on the proliferation, migration and invasion of papillary thyroid cancer (PTC) cells, and explore the molecular mechanism involved. Bioinformatics analyses based on numerous public databases were conducted to profile the expre...

CircATRNL1 Facilitates Malignant Progression of Non–Small Cell Lung Cancer via the miR-103a-3p/IGFBP3/PI3K-AKT Axis

The findings highlight the CircATRNL1/miR-103a-3p/IGFBP3/PI3K-AKT axis as a potential regulatory mechanism contributing to in vitro migration and invasion in NSCLC.

CircENO1 drives gastric cancer progression via SPI1-mediated transcriptional activation of ENO1.

BACKGROUND Circular RNAs (circRNAs) are critical regulators of tumor biology. However, the role of circENO1 in gastric cancer (GC) remains unclear. This study investigated the biological function and molecular mechanism of circENO1 in GC. METHODS CircENO1 expression was evaluated using a publicly available dataset, c...

LncRNA DNAJC3-AS1 promotes gastric cancer malignancy through miR-576-5p-mediated upregulation of LYPLA1.

It is suggested that lnc-DNAJC3-AS1 promotes GC progression, at least in part, through the miR-576-5p/LYPLA1 pathway, providing a potential target for GC treatment.

CircUBE2I regulates YAP/TAZ signaling pathway through miR-659-3p/PSMA1 axis to promote human lung adenocarcinoma cell progression.

Circular RNAs (circRNAs) exhibit wide expression across human tissues and play pivotal roles in tumorigenesis and cancer progression. However, studies regarding the function and mechanism of circRNAs in lung adenocarcinoma (LUAD) are insufficient, it needs to be further explored. This investigation aimes to describe dy...