TL;DR
This study implicates specific plasma proteins in FTD pathogenesis, with subtype-dependent effects, and identifies potential biomarkers for stratification and therapeutic targets.
Dementia is clinically and biologically heterogeneous, and genetically supported plasma protein associations across dementia subtypes remain incompletely characterized. We aimed to genetically prioritize plasma proteins associated with overall dementia and major dementia subtypes using proteome-wide Mendelian randomiza...
Many AD pQTLs in CSF were enriched in neuroimmune activation, suggesting a genetic basis for neuroimmune dysregulation in AD, and how genetic variation shapes protein expression in the central nervous system is highlighted.
The model’s accurate estimation of disease stages underscores the value of DEBM for patient stratification, offer a promising tool to support clinical trial design and provide a temporal ordering of multiple CSF proteins.
These findings delineate the first causal blueprint of the OP plasma proteome, and NUDT2 is highlighted as a plausible metabolic regulator of bone formation and accelerates the development of novel therapeutics for osteoporosis.
Blood metabolomics capture variation in biological aging, but the circulating proteins that underlie or accompany metabolomic aging and its links to disease and mortality remain underexplored. Here, we integrated metabolomics, proteomics and genetics from UK Biobank to characterize the protein architecture of metabolom...
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