METTL3–YTHDF1–driven m6A enhancement of MYC signaling orchestrates DNA repair and metabolic reprogramming to promote chemoresistance in colorectal cancer

Kai Wang Song Geng Zhengping Xiao Hong Jiang

Jul 2026 · Molecular and Cellular Biochemistry · Vol 481, pp. 3831 - 3856 · 0 citations · 59 references

Medicine

TL;DR

It is revealed that m6A-regulated MYC signaling orchestrates DNA repair and metabolic remodeling to promote CRC chemoresistance and highlights the METTL3–YTHDF1–MYC axis as a promising target for predictive precision therapy and combined therapeutic interventions.

DOI PubMed Semantic Scholar

View source

Similar papers

Sep 2026

METTL3-m6A-IGF2BP2 Axis-Mediated Stabilization of MTFR1 Promotes Glycolytic Reprogramming in Colorectal Cancer.

A METTL3-m^6A-IGF2BP2 axis maintains MTFR1 expression to drive glycolytic reprogramming and CRC progression, and represents a prognostic biomarker and a potential therapeutic node linking epitranscriptomic regulation to metabolic adaptation in CRC.

Li-Qiang Wei, Deng-He Liu, Chun-Yu Lin et al. · Journal of Gastroenterology... · 0 citations

Review Sep 2026

Targeting the METTL5–MGST1 axis for cancer therapy: molecular mechanisms and therapeutic implications

This review comprehensively examines the structural biology, expression patterns, molecular mechanisms, and cancer-type-specific functions of both METTL5 and MGST1, with particular emphasis on their functional interdependence.

Abinash Nayak, S. Nishank · Molecular Biology Reports · 0 citations

Open access Aug 2026

Epigenetically driven GAS2L3 enforces non-canonical cell cycle progression to promote osimertinib resistance in lung adenocarcinoma

These results uncover a metabolism-epigenetics–cell cycle interface that may represent a therapeutic vulnerability in EGFR-mutant LUAD and identify a glycolysis–H4K8la–GAS2L3 axis that drives noncanonical cell-cycle reprogramming independently of classical Cyclin–CDK activation, thereby promoting acquired osimertinib r...

Shu-Man Zhen, Xiaohui Bai, Shu-Tang Liu et al. · Cell Death Discovery · 0 citations

Open access Sep 2026

MCM10, regulated by METTL3/ YTHDF1-mediated m6A modification, contributes to colorectal cancer progression through induction of M2 macrophage polarization

MCM10 is aberrantly overexpressed in CRC and linked to worse clinical outcomes and its oncogenic effects involve METTL3/YTHDF1-mediated mRNA stabilization and enhanced M2 macrophage polarization, suggesting a potential role in immune microenvironment modulation.

Qiao Qu, Zhilong Li, Da-Lu Wang et al. · Cellular and Molecular Life... · 0 citations

Open access Sep 2026

The long non-coding RNA-encoded microprotein MKKS3 drives colorectal cancer chemoresistance

The role of MKKS3 is identified as a key player in enhancing oxaliplatin resistance by interacting with TRIM29, facilitating DNA repair and suppressing immune responses, and pointing towards future research on MKKS3 inhibitors as potential anti-CRC drugs.

Hui-Fang Hu, Qi Zhou, Jia-Zhen Huang et al. · Experimental and Molecular M... · 0 citations

Open access Sep 2026

Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian Cancer

This study reveals a previously unrecognized mechanism linking metabolism to epigenetic regulation through platinum-induced remodeling and establishes the MAT2A-SAM axis as a promising therapeutic target to enhance platinum sensitivity by abrogating DNA damage response and OCSC enrichment and ultimately reduce OCSC-dri...

Shu Zhang, Zhen Fu, Yan-Chi Zhou et al. · bioRxiv · 0 citations