Induced pluripotent stem cell–derived macrophages (iMacs) in translational medicine: Disease models, drug testing, and therapeutic applications

Highly Efficient Derivation of Functional Human-Induced Pluripotent Stem Cell-Derived Macrophages under Serum-Free Conditions to Study Innate Immune Responses

A robust, reproducible, efficient serum-free and feeder-free protocol for generating functional iMacs and characterizing their innate immune properties, providing a versatile model for investigating innate immunity, host-pathogen interactions, and interferon signaling.

High-throughput platforms for genetic perturbation screening using CRISPR/Cas9 in human iPSC-derived macrophages for drug discovery

A scalable, semi-automated, and physiologically relevant hiPSC-derived macrophage model, rigorously characterised through deep comparative multi-omics is established and how genetic perturbations alter pro- and anti-inflammatory transcriptional signatures and significantly impact functional phenotypes are showcased.

Immunomodulatory Properties of Mesenchymal Stem Cells and Their Extracellular Vesicles: Potential Clinical Applications in Autoimmune Diseases

Mesenchymal stem cells (MSCs)/mesenchymal stromal cells and their extracellular vesicles (EVs), particularly exosomes, have emerged as therapeutic candidates in regenerative medicine due to their multipotency, low immunogenicity, and extensive immunomodulatory properties. This narrative review provides a narrative synt...

Engineered mesenchymal stem cell-derived extracellular vesicles as programmable biomaterial platforms for liver fibrosis: design principles, manufacturing and clinical translation

Liver fibrosis remains a major unmet clinical challenge characterized by persistent activation of hepatic stellate cells (HSCs), chronic inflammatory remodeling, and impaired hepatocyte regeneration. Although mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as promising cell-free therapeutics...

TGFB1-Engineered Induced Mesenchymal Stromal Cells Exhibit High Immunomodulatory Potency and Durably Reprogram Synovial Macrophages in Osteoarthritis

[Mesenchymal Stem Cells as Anti-Tumor Therapeutics-Current Status and Challenges].