In silico and in vitro evaluation of synergistic anticancer effects of erucin and kaempferol from Eruca sativa against human A549 non-small cell lung cancer cells (NSCLC)

Evaluation of the anticancer effects of kaempferol using in vitro assays and [99mTc]Tc-PSMA SPECT/CT imaging in a DMBA-induced breast cancer model

Kaempferol is a naturally occurring flavonoid with reported anticancer properties; however, its effects on breast cancer cells and tumor-associated molecular imaging require further investigation. This study evaluated the effects of kaempferol using complementary in vitro assays and a 7,12-dimethylbenz [a]anthr...

Systemic Explanation of Alpinia officinarum’s Analyzed Compounds and Its Anti-Cancer Mechanism Based on In Vitro Analysis and Network Pharmacology in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking ER, PR, and HER2 expression, often associated with poor prognosis, early relapse, and resistance to conventional chemotherapy. Due to the limited availability of targeted therapies, natural products have gained attention for their st...

Beauvericin exhibits antitumor activity in pancreatic cancer cells: Integrative analysis suggests potential modulation of the KEAP1-NRF2-HMOX1 axis and survival signaling pathways

To investigate the anticancer effects of Beauvericin (BEA) and elucidate its potential mechanisms in pancreatic cancer cells, a malignancy characterized by marked heterogeneity and frequent chemoresistance. The effects of BEA on the proliferation, migration and apoptosis of Mia PaCa-2 cells were evaluated via CCK-8,...

Phytochemical Characterisation and In Vitro Anticancer Potential of Combretum indicum Leaf Aqueous Extract Against A549 Cells

The aqueous leaf extract of C. indicum demonstrated promising antioxidant and anti-cancer potential and stigmasterol emerged as the most promising lead phytoconstituent against EGFR, ALK, ROS1, PI3K, and MET.

Proteomic regulation of anti-proliferative and anti-migratory activity by potent phytochemicals from Pistacia integerrima J.L. Steward Ex Brandis via PI3K, AKT1, and KRAS for Lung Cancer

Elucidating the potential anti-liver cancer mechanisms of the medicinal food Rosa roxburghii Tratt. by integrating HPLC-Q Exactive MS/MS, network pharmacology, and in vitro validation.

This study integrated HPLC-Q Exactive Plus MS/MS analysis, network pharmacology, molecular docking, and in vitro assays to investigate the anti-liver cancer mechanisms of flavonoid components from Rosa roxburghii Tratt. (RRT) ethanol extract. A total of 52 flavonoids were identified, including 15 active compounds assoc...