Integrated bioinformatics and experimental validation reveal that kaempferol ameliorates intervertebral disc degeneration via dual anti-inflammatory and anti-aging pathways.

A novel target associated with senescence and inflammatory signaling in human intervertebral disc degeneration

ZEB2 as a central transcription factor and novel biomarker in intervertebral disc degeneration

Low back pain is commonly driven by intervertebral disc degeneration (IDD), a condition marked by the deterioration of the extracellular matrix (ECM), the buildup of senescent cells, and ongoing chronic inflammation. The molecular basis of IDD is still not fully elucidated, especially regarding how transcription fact...

The m6A methyltransferase METTL3 in intervertebral disc degeneration: from molecular mechanisms to therapeutic potential

Intervertebral disc degeneration (IDD) is the fundamental pathological process underlying low back pain, a major cause leading to disability worldwide. As the most prevalent methylation modification in eukaryotic RNA molecules, N6-methyladenosine (m 6 A) is involved in various diseases and cellular processes by reg...

Elucidation of Baicalein’s Anti-Intervertebral Disc Degeneration Mechanism Through Network Pharmacology and Experimental Validation

This study aims to elucidate the biological effects of Baicalein (BA) on intervertebral disc degeneration (IDD) and the potential mechanisms involved. Network pharmacology analysis was performed to identify the core targets and signaling pathways responsible for the therapeutic effects of BA on IDD. In vitro validation...

Identification of AHR, UACA, GCLM, and GSTZ1 as candidate genes associated with metabolic alterations in intervertebral disc degeneration

A miRNA–transcription factor–mRNA regulatory network was constructed and validated core gene dysregulation via RT-qPCR in primary human nucleus pulposus cells, providing candidate molecular indicators for IVDD severity assessment and insights for future mechanistic studies.

Ginsenoside Rh2 Attenuates Intervertebral Disc Degeneration by Modulating the PI3K/AKT Signaling Pathway to Suppress Apoptosis

Intervertebral disc degeneration (IVDD) is a major cause of chronic low back pain and imposes a substantial socioeconomic burden. Ginsenoside Rh2 (Gin-Rh2), a bioactive ginseng compound with antioxidant properties, may have therapeutic potential in IVDD, but its effects and underlying mechanisms remain unclear. Here, w...