Aug 2026· Free Radical Biology & Medicine· Vol 256, pp. 15-30· 0 citations
Medicine
TL;DR
In vitro experiments revealed that IMA induced PANoptosis, characterized by membrane blebbing and swelling, pyknosis, as well as rupture of the nuclear and plasma membranes observed, which suppressed IMA-induced PANoptosis, and improved granulosa cell viability and oocyte quality.
Collectively, ART suppresses PC growth, survival, migration, and EMT by targeting the STAT3 and ROS/SHP-1 signaling pathways, supporting its potential as a therapeutic candidate for PC.
Young Y. Jung, Alamelu Nachiyappan, Na Young Kim et al.· Archives of Biochemistry and...· 0 citations
Initial evidence is provided that marbofloxacin induces metabolic and molecular rewiring in BC, highlighting its promise as a repositionable therapeutic candidate.
M. Yavuz, F. R. P. Dewi, Ilknur Keskin et al.· Pharmaceuticals· 0 citations
Despite advances in current therapeutic strategies, osteosarcoma remains a highly aggressive malignancy with limited treatment options. Rutaecarpine (Rut), an indolopyridoquinazolinone alkaloid with selective cyclooxygenase-2 inhibitory activity, has been reported to possess diverse pharmacological properties; however,...
Hyung-Mun Yun, Kyung-Ran Park· Biochimica et Biophysica Act...· 0 citations
Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major limitation to the clinical use of DOX, highlighting the need for effective cardioprotective strategies. Although acteoside (ACT), a natural compound with antioxidant properties, has shown potential cardioprotective effects, its role in DIC, particularly in the r...
Meng Wang, Che Wang, Zhi-Hao Liu et al.· European Journal of Pharmaco...· 0 citations
DMC is identified as a thermosensitive inhibitor of SIRT3 and mechanistic insights into its potential to disrupt mitochondrial homeostasis for targeted cancer therapy are provided.
