Jul 2026· Open Access Government· Vol 51, pp. 190-191· 0 citations
Abstract
Heat shock factor 1 (HSF1) plays a pivotal role in maintaining neuronal health, and its dysfunction contributes significantly to the progression of Huntington’s disease. Rocio Gomez-Pastor tells us more. Huntington’s disease (HD) is a devastating, inherited neurodegenerative disorder marked by progressive motor dysfunction, cognitive decline, and psychiatric symptoms. At its genetic core lies a mutation in the huntingtin (HTT) gene, specifically an expansion of CAG trinucleotide repeats that encode an abnormally long polyglutamine (polyQ) tract in the huntingtin protein. (1) This mutation transforms an otherwise essential cellular protein into a toxic species prone to misfolding and aggregation. Over time, these molecular disturbances selectively damage neurons, particularly in the striatum and cortex. (2,3)
Huntington's disease (HD) is a life-threatening neurodegenerative disease caused by a mutation in Huntingtin (HTT). Neuropathology in HD is marked by a progressive loss of neurons in the caudate putamen and the deposition of mutant HTT aggregates as cytoplasmic and nuclear inclusions. At present, no disease-modifying t...
An Wu, Xue-Yi Li· Journal of Huntington's Dise...· 0 citations
Investigations using various experimental techniques reveal that faulty neuroplasticity develops before the formation of visible protein aggregates, leading to synaptic dysfunction and specific loss of striatal medium spiny neurons in Huntington’s Disease.
Klotho is a promising neurochemical modulator with disease-modifying properties in HD, and its multifunctional protective activities are consistent with important pathological markers of HD, necessitating more preclinical and clinical studies to confirm its translational value.
Shikha Singh, Avnesh Kumar, Falguni Goel et al.· Current molecular medicine· 0 citations
This review critically summarizes the design, synthesis, and structural motifs of small-molecule candidates, clinically used agents, and antioxidant natural products, providing a structural framework to guide the rational design and development of next-generation anti-HD compounds.
Yi-Tian Jiang, Xin-Yi Chen, Zhao-Xin Xu et al.· European journal of medicina...· 0 citations
Discussing the effectiveness of the recent therapy for Huntington's illness is the main ambition in this regard, and a variety of treatments are accessible to lessen the symptoms of Hunti ngton's disorder, and efficient solutions for its chorea.
High mobility group box 1 (HMGB1) is a crucial modulator of neuroinflammation in AD, according to new research, and a viable treatment approach for reducing neuroinflammation and associated pathologies with AD is to target HMGB1-mediated signalling networks.
Prashant Tyagi, Sneha Kumari, Prajjwal Sharma et al.· International Immunopharmaco...· 1 citation
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