This review examines the biological rationale, experimental evidence, and potential clinical applicability of radiosurgical ablation of the choroid plexus for iNPH to determine the feasibility and efficacy of SRS as a potential non-invasive therapeutic option for iNPH.
BACKGROUND AND OBJECTIVES
Normal pressure hydrocephalus (NPH) affects approximately 0.2% to 2.9% of adults older than 65 years and is characterized by progressive gait impairment, cognitive decline, and urinary incontinence. Cerebrospinal fluid shunting is the mainstay of treatment but carries a risk of overdrainage, l...
S. Frome, Daniel N. de Souza, Amogh Iyanna et al.· Neurosurgery· 0 citations
OBJECTIVE
Hydrocephalus can result from mass lesions for several reasons. Due to limited numbers of adult patients with mass lesions in studies that examine outcomes of endoscopic third ventriculostomy, success in this population is unclear. Additionally, the role of other ventriculoscopic procedures in the management...
Ryan M. Hess, D. Ormond· Journal of Neurosurgery· 0 citations
AbstractIdiopathic normal pressure hydrocephalus presents distinctive ethical challenges, since its treatment requires lifelong device-based therapy in the setting of diagnostic and prognostic uncertainty. Although randomized controlled trials and pooled analyses demonstrate that cerebrospinal fluid shunting can substa...
K. Iserson· Journal of Clinical Ethics· 0 citations
Surgically inoperable cerebral arteriovenous malformations (AVMs), including deep-seated, large, and eloquently located lesions, remain difficult to manage because the cumulative risk of hemorrhage must be balanced against the morbidity of curative microsurgery. Contemporary stereotactic radiosurgery (SRS) has expanded...
Shinya Yuki, Dong-Hoon Lee, Yusuke S. Hori et al.· Journal of clinical neurosci...· 0 citations
Background and Objectives There is ongoing clinical equipoise regarding the optimal treatment strategy for symptomatic cerebral cavernous malformations (CCMs). The aim of this study was to estimate the causal effect between CCM intervention (microsurgical resection or stereotactic radiosurgery) and clinical outcomes du...
Abel Clemens Adriaan Sandmann, D. Verbaan, J. Coutinho et al.· Neurology· 0 citations
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