Design of Multi-Stimuli Responsive Nanocarriers for Co-delivery of Phytochemicals and Immune Modulators: A Synergistic Approach to Overcoming Tumor Resistance
This review examines the rationale for co-delivering phytochemicals and immune-modulating agents, two classes of therapeutics that act through complementary mechanism although not always synchronized.
The paper reviews current developments concerning stimulus-responsive nanoparticles; it also describes how these agents work as a means to treat cancers precisely.
C. J. Jiflin, Mohana Sundaram Somasundharam Pushpanathan, Jeevitha Dhayalan et al.· BOHR Journal of Pharmaceutic...· 0 citations
Abstract Tumor immunotherapy has substantially advanced cancer treatment by activating or enhancing the antitumor immune response. However, tumor heterogeneity, the immunosuppressive tumor microenvironment (TME), and therapeutic resistance limit the efficacy of single-agent immunotherapy, making mechanistically complem...
Tian-Ying Sun, Chuang Liu, Jiang Zhu et al.· International Journal of Nan...· 0 citations
This review provides a concise framework for the rational design of programmable, multi-responsive polymeric nanomedicines for TNBC therapy and summarizes recent advances in pH-, redox-, ROS-, hypoxia-, photo- and temperature-responsive polymers.
Adnan Murad Bhayo, Ying Li, Alaa R. Aboushanab et al.· Pharmaceutics· 0 citations
This review highlights recent progress in the design and application of stimuli-responsive MSNs for cancer therapy, with particular emphasis on mechanisms of intracellular uptake, factors influencing cellular internalization, and strategies for controlled drug release.
U. Abbasi, Md. Saifuddin, Mahak Fatima et al.· Journal of drug targeting (P...· 0 citations
This review systematically summarizes targeted nanomedicines constructed from mainstream carriers, including polymeric, metallic, and biomimetic nanoparticles, and discusses the future prospects of artificial intelligence-assisted optimization strategies for nanomedicine development.
Rui-Chao Li, Ze-Yuan Sun, Si-Nian Li et al.· International Journal of Pha...· 0 citations
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