Sep 2026· World Journal of Clinical Cases· Vol 14· 0 citations· 9 references
TL;DR
Although cryptococcosis is known to have a high case fatality ratio, in this patient, histopathological examination of skin lesions prompted the timely initiation of therapy, and hence, a favorable outcome was achieved.
Abstract
Background
Cryptococcosis is an infection caused by Cryptococcus species, an invasive fungus. The fungus is transmitted through the inhalation of spores, and causes opportunistic infection that affects the central nervous system, lungs, and skin. Soil, fruits, wood, and bird excreta commonly harbor the fungus. Two cryptococcal species are known to cause infection in humans. Cryptococcus neoformans is known to affect immunocompromised individuals, whereas C. gattii develops disease in immunocompetent individuals.
CASE SUMMARY
We report a case of disseminated cryptococcosis presenting as molluscoid skin lesions, followed by meningo-encephalitis.
Conclusion
Collaboration and communication among interdisciplinary teams is essential in the diagnosis of cryptococcosis. Any nonhealing skin lesion should be biopsied for histopathology. Although cryptococcosis is known to have a high case fatality ratio, in our patient, histopathological examination of skin lesions prompted the timely initiation of therapy, and hence, a favorable outcome was achieved.
A 67-year-old woman who presented with progressive skin erythema and pustules for two months, unresponsive to topical halometasone is reported, demonstrating that primary cutaneous infections can occur in non-transplant hosts.
Chun-Li Yang, Zheng Lin, Dong-Ping Yang et al.· Frontiers in Medicine· 0 citations
To comprehensively review clinical, diagnostic, and therapeutic data on the global epidemiology of cryptococcosis in apparently immunocompetent patients with no or only a few minor medical conditions who were previously healthy. While cryptococcosis is often regarded as a rare presentation in presumably healthy individ...
C. Firacative, Andrés Cendales-Regalado, Óscar Gil et al.· Current Tropical Medicine Re...· 0 citations
Cryptococcosis mainly affects immunocompromised hosts but can also occur in immunocompetent individuals, often presenting with non-specific pulmonary radiological lesions and asymptomatic clinical course, which frequently causes misdiagnosis and delayed treatment. Diagnostic challenges arise when central nervous system...
Siffat Ullah· Science Set Journal of Medic...· 0 citations
Cryptosporidiosis is a diarrheal disease caused by the protozoan Cryptosporidium spp. and is a major cause of morbidity and mortality in children and individuals with weakened immune systems, such as those with HIV/AIDS, cancer, or organ transplant recipients. This infection is transmitted via the fecal-oral route, pri...
M. M. Sholihah, E. Nurhayatun, Dhani Redhono et al.· Modern Medicine· 0 citations
Cryptococcus neoformans and Cryptococcus gattii are a globally distributed fungal pathogen that causes a significant number of cryptococcosis worldwide, especially among immunocompromised individuals, although immunocompetent may also be affected. This infection begins when Cryptococcus is inhaled from the environment...
D. F. D. de Jesus, Larissa Dunkl Brujas, T. Barreto et al.· Future Microbiology· 0 citations
Abstract Introduction Nocardia is a rare group of opportunistic bacteria that normally causes infections in immunocompromised patients. It can involve multiple organ systems: most frequently the lungs, followed by the skin, central nervous system, bones, and joints. Within this group, Nocardia farcinica is among the mo...
Gabor-Siklodi Szabolcs-Attila, Muresan Mircea Gabriel, Kiss Botond-Istvan et al.· Acta Marisiensis - Seria Med...· 0 citations
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