This review aims to provide a comprehensive and up-to-date overview of the molecular biology of S. aureus biofilms, biofilm-associated antimicrobial resistance, interactions with the host, polymicrobial interactions, and emerging therapeutic strategies, and to highlight the ongoing challenges and future directions in the prevention and treatment of persistent biofilm-associated infections.
This review provides an integrated overview of the molecular and genetic determinants governing biofilm development, including surface attachment, matrix biosynthesis, quorum-sensing networks, cyclic-di-GMP signaling, maturation, and dispersal.
Tanvee Chakraborty, Madhuchhanda Chatterjee, Sayanika Das et al.· Infection, Genetics and Evol...· 0 citations
Biofilms are structured communities of microorganisms that adhere to biotic or abiotic surfaces and are enclosed within a self-produced matrix of extracellular polymeric substances. The transition of microbial cells from the free-living planktonic state to the sessile biofilm mode of growth is a major survival adaptati...
K. Amaihunwa, Osinachi Nwachukwu, D. Ofili et al.· World Journal of Advanced Re...· 0 citations
Bacterial pathogens employ diverse virulence factors to establish infection, evade host defences and promote disease progression. This review examines the virulence strategies of two clinically significant human pathogens, Staphylococcus aureus and Mycobacterium tuberculosis, which represent contrasting paradigms of ba...
C. Malli, Saachi S. Shetty· AJ Journal of Medical Scienc...· 0 citations
The most common type of microbial life in nature is found in bacterial biofilms, which are organized colonies attached to surfaces. They are thought to be the cause of up to 80% of human chronic illnesses and over two-thirds of microbiological infections. The global antimicrobial resistance (AMR) epidemic is intimately...
S. Barik, P. Mohanty, Mugdha Sinha et al.· International Journal of Env...· 0 citations
Bacterial biofilm is a community in which the microorganisms are organized and surround themselves within self-produced matrices that are attached to surfaces, which help in protecting them against insults, and this resistance is reported to be the major cause of chronic infections and also those infections which are r...
Mayadah Mohammed Ridha null Abdul-Razzaq· Journal of Microbiological S...· 0 citations
ABSTRACT The ESKAPE group of pathogens comprises Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp., which are capable of developing profound biofilms while infecting host tissues and medical devices. In addition to acting as a barr...
Shatarupa Biswas, Sayan Bhattacharyya, Sonali Biswas et al.· Infection and Immunity· 0 citations
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