Single-cell profiling reveals MMP7-associated epithelial transition and immune-stromal remodeling in esophageal carcinogenesis

Cancer-associated fibroblasts and immune remodeling in laryngeal squamous cell carcinoma: evidence and translational perspectives

An evidence-stratified framework for CAF heterogeneity in LSCC is established and clarifies the translational value and current limitations of stroma-targeted strategies and provides a structured foundation for hypothesis-driven clinical and experimental investigation in laryngeal cancer.

The atypical cadherin CELSR2 regulates distinct epithelial–mesenchymal states and oxidative phosphorylation in triple-negative breast cancer

These findings identify CELSR2 as a previously unknown regulator of epithelial-mesenchymal plasticity and reveal that heterogeneous CELSR2 expression shapes spatially and functionally distinct tumor cell populations, thereby contributing to intratumoral heterogeneity in TNBC.

Cancer-associated fibroblast-derived extracellular vesicles promote pancreatic cancer progression via the RAP1B/ANLN axis

It was demonstrated that CAF-derived EVs enhanced the proliferative, migratory and invasive capacity of PDAC cells across two independent cell lines, as assessed by Cell Counting Kit-8 assays and Transwell migration and Matrigel invasion assays.

P1.105. Epithelial–Mesenchymal Plasticity Underlies Adaptive Resistance to FLOT Chemotherapy in Esophageal Adenocarcinoma

Findings suggest a dynamic, reversible model of chemoresistance driven by EMP rather than fixed cell identity, which may support the development of treatment strategies that limit resistance and improve patient response to perioperative chemotherapy.

Single-cell profiling reveals disruption of cell-cycle homeostasis following JDP2 depletion in colorectal epithelial cells

All-trans retinoic acid-driven immune remodeling in esophageal squamous cell carcinoma revealed by single-cell transcriptomics.

Esophageal squamous cell carcinoma (ESCC) remains a highly lethal malignancy with limited durable responses to current therapies. Our previous work showed that all-trans retinoic acid (ATRA) upregulates the deubiquitinase OTUD6B and suppresses ESCC stemness. Here, we integrated in vivo pharmacological treatment, single...