This work reports for the first time that the atypical BCL2 protein BCL2L13 controls caspase-3 activity and cytochrome C release in neural stem/progenitor cells and identifies BCL2L13 as a novel target of the cooperative action of microRNA-124 and microRNA-137, both upregulated in the dentate gyrus shortly after kainic acid-induced seizures.
A neurogenic lineage in the adult human hippocampal subgranular zone is identified and evidence for a stalled neurogenic process in MDD is provided, associated with transcriptional regulation, stress-related reprogramming and interferon signaling across developmental stages.
Madeleine S Peng, Jia-Jia Jiang, Luciana Polizzi et al.· Nature Medicine· 2 citations
DOT1L is established as a barrier between these astrocyte states, limiting differentiation of the astrocytes expressing phagocytosis marker genes, and lowering the DOT1L-mediated epigenetic barrier strongly favours appearance of astrocytes with limited phagocytosis properties and reactivation of progenitor programs.
Maira Mirza, Tobias Hohl, Camila L. Fullio et al.· bioRxiv· 0 citations
Adult hippocampal neurogenesis can be enhanced or even triggered by extrinsic stimuli, but the lineage-specific regulatory changes that accompany a stimulated neurogenic response remain undefined. We used recombinant human erythropoietin (rhEPO), a defined influencing factor that enriches newly formed pyramidal neurons...
U. Çakır, Federica Mantovani, Souad Youjil Abadi et al.· bioRxiv· 0 citations
It is found that a large proportion of granule neurons predominantly express the C2 gene program during early postmitotic differentiation, but that C2 genes are downregulated in a subset of neurons during late postnatal development, leading to comparable proportions of C1 and C2 neurons in adulthood.
This dataset defines transcriptomic programs underlying key cellular alterations in TLE, enabling mechanistic dissection of epileptogenesis, and term this microglia population epilepsy-associated microglia (EAM).
Victoria Ho, Ruth Tjondropurnomo, Jennifer Nguyen et al.· iScience· 0 citations
It is shown that Wnt/β-catenin signaling regulates NG2 glial fate after focal cerebral ischemia and suggested that its modulation may enable directed lineage reprogramming in the injured adult brain.
Tomas Knotek, L. Janečková, J. Kriska et al.· Communications Biology· 0 citations
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