TL;DR
Among all measures, FA, reflecting white matter integrity, was most sensitive in detecting neural changes following TMS, highlighting its potential utility as a treatment-responsive biomarker.
Background/Objectives: Quantitative magnetic resonance imaging (MRI) volumetry may provide an objective approach for detecting subtle longitudinal structural brain changes in patients with epilepsy. This retrospective longitudinal study investigated regional and global brain volume changes observed during levetiracetam...
Background and Objective: For their acceptance as endpoints in clinical trials, biomarkers and clinical outcome assessment (COA) measures should show reliability by being reproducible (precise) and responsive to change. We evaluated precision and responsiveness of MRI-derived brain volume metrics and various COAs in ce...
Quantitative magnetic resonance imaging (qMRI) supports both basic neuroscience and clinical research, providing the foundation for longitudinal studies of brain development, aging, and neurological disease. However, its validity rests on a little-studied assumption: that physical relocation of imaging hardware leaves...
The hippocampus is crucial for learning, memory, and stress regulation, but is vulnerable to influences that compromise its structural and metabolic integrity. Proton magnetic resonance spectroscopy (MRS) enables in vivo quantification of hippocampal neurochemistry, yet the absolute and relative reliability of these...
Objectives: Developing sensitive imaging biomarkers is critical for capturing early brain alterations in Alzheimer’s disease. This exploratory study aimed to evaluate how multiparametric magnetic resonance imaging (MRI) measures, including chemical exchange saturation transfer (CEST) imaging, can detect early cognitive...
Purpose Brain ageing involves interrelated changes in molecular processes, neuroinflammatory mechanisms, brain macro- and microstructure, sleep physiology, and cognition. The 50 to 70 years age range represents a critical transition period, in which these subtle alterations may precede measurable cognitive decline and...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
