Aug 2026· Virulence· Vol 17· 0 citations· 79 references
Medicine
TL;DR
The UPEC pangenome in Ecuador was characterized, focusing on the virulome and resistome of 142 genomes sequenced using whole-genome sequencing (WGS).
Abstract
ABSTRACT Uropathogenic Escherichia coli (UPEC) is one of the leading causes of bacterial Urinary Tract Infections (UTIs) worldwide. In this study, we characterized the UPEC pangenome in Ecuador, focusing on the virulome and resistome of 142 genomes sequenced using whole-genome sequencing (WGS). Our analysis revealed a structure of 16,732 genes, including a conserved core of 3,385 genes and a dynamic accessory genome of 13,347 genes. The ST131 lineage was predominant, accounting for 42.3 % of the total, whereas the O25:H4 serotype was present in 42.96 % of the cases. The resistome was associated with a large accessory gene repertoire, with 3,712 significant associations identified across 29 antimicrobial resistance genes (ARGs). The virulome was organized into 23 main profiles, with adhesion and siderophore genes being the most abundant. These findings demonstrate the presence of high-risk variants in terms of virulence and resistance circulating in Ecuador, which requires the establishment of improved health control strategies in the region.
Uropathogenic Escherichia coli (UPEC) is the predominant causative agent of urinary tract infections. The UPEC strain, CFT073, has a mosaic genome containing 60 genomic islands enriched in virulence genes. In this study, we explore the small proteome of CFT073 using ribosome profiling (Ribo-seq) coupled with RNA sequen...
Wen-Ting Liu, R. Gelhausen, Lisa Werland et al.· bioRxiv· 0 citations
Abstract This secondary in silico study analysed 36 Escherichia coli draft genome assemblies from Zambia to characterize the virulence gene profiles of extraintestinal pathogenic E. coli (ExPEC) and to relate them to mobilome proxies, namely plasmid replicons and prophage content. All assemblies met plausibility thresh...
Frank Chilombolwa Nyondo· Access Microbiology· 0 citations
ABSTRACT Here, we described the resistome and virulome of worldwide K. pneumoniae ST25 (Kp-ST25) genomes and established their phylogenetic relationship. Out of a collection of 32 KPC-2-producing Kp-ST25 recovered in Argentina during 2015–2017, eight isolates were selected for whole-genome sequencing (WGS). Additionall...
D. Cejas, Francisco González-Espinosa, V. di Pilato et al.· Microbiology spectrum· 0 citations
The genomic landscape of A. baumannii in Mexico has diversified post-COVID, with evidence of inter-regional transmission, virulome expansion, mobilome-driven ARG dissemination, and metabolic adaptation, and the urgent need for coordinated genomic surveillance, functional and clinical validation of adaptation signals, a...
Moisés A. Alejo, Miriam Sarahi Lozano Gamboa, Brian Muñoz Gomez et al.· Frontiers in Public Health· 0 citations
ABSTRACT Neisseria gonorrhoeae, an obligate human pathogen, causes the sexually transmitted infection gonorrhea. Delayed treatment or immunodeficiencies can result in a higher risk of disseminated gonococcal infection (DGI), where the infection spreads to normally sterile anatomic sites, including the bloodstream. The...
N. Nunnally, J. Stoudenmire, O. Harrison et al.· Microbiology spectrum· 0 citations
Gonorrhea is a global public health issue, with the highest number of cases in Peru originating from Lima, the capital. This study conducted whole genome sequencing on 72
Neisseria gonorrhoeae
isolates collected from various regions of Peru between 2018 and 2023 to characterize their resistome and virulome. Among...
Ana Jorge-Berrocal, Fabiola Salazar-Quispe, Yuli J. Barrios-Cárdenas et al.· Scientific Reports· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
