Aug 2026· Journal of Agricultural and Food Chemistry· Vol 74 32, pp.
25183-25201
· 0 citations· 75 references
Medicine
Abstract
Kaempferol, a widely present dietary flavonoid in numerous fruits and vegetables, possesses antiobesity potential with unclearly defined mechanisms. This study investigated how kaempferol regulates adipogenesis in 3T3-L1 preadipocytes and exerts antiobesity effects in high-fat diet (HFD)-induced obese mice. Kaempferol inhibited preadipocyte differentiation at the early mitotic clonal expansion (MCE) stage by S-phase (18 h) and G2/M-phase (24 h) cell cycle arrest. Mechanistically, this action was mediated through inhibition of the PI3K/AKT/GSK3β pathway. Application of the AKT activator SC79 confirmed that kaempferol suppresses AKT phosphorylation to inhibit terminal adipogenesis. In vivo, kaempferol significantly alleviated HFD-induced body weight gain, adiposity, dyslipidemia, and insulin resistance. Transcriptomic and histological analyses revealed that kaempferol reversed obesity-associated upregulation of cell cycle and metabolic pathways in white adipose tissue and alleviated adipose tissue fibrosis. These findings underscore the potential of kaempferol as a promising functional food ingredient for preventing obesity and related metabolic diseases.
Type 2 diabetic osteoporosis (T2DOP) features impaired bone quality and high fracture risk, with unclear pathogenesis and limited targeted therapies. This study explored the therapeutic effect and molecular mechanism of kaempferol against T2DOP via m⁶A modification and ferritinophagy-dependent ferroptosis using bioinfo...
GA alleviated LF by modulating PI3K/AKT/NF-κB signaling to inhibit M1 macrophage polarization and the pathogenic macrophage-HSC interaction, highlighting its potential as an immunomodulatory therapeutic candidate for LF.
Jingxin He, Chen Zhang, Yingtian Luo et al.· International Immunopharmaco...· 0 citations
ETHNOPHARMACOLOGICAL RELEVANCE
Geranium (Geranium wilfordii Maxim.) has traditionally been used as a folk medicine in East Asia and Europe. Geraniin, the major bioactive constituent of geranium, has been reported to ameliorate dyslipidemia and insulin resistance, but its effects against adipose metabolic dysfunction re...
Yi Feng, Xiao-Yu Liu, Xin-Yi Zhang et al.· Journal of Ethnopharmacology· 0 citations
With the development of obese adipose tissue (AT), adipocytes undergo pathological changes from inert energy storage to excessive and active endocrine organs associated with disease hazards. Methyltransferase 3 (METTL3) is an RNA methyltransferase with key roles in AT development, functional maintenance and metabolic h...
Shuang-Xi Tu, Xiao-Dan Wang, Zhen-Bo Wang et al.· Molecular Medicine Reports· 0 citations
Obesity is a major metabolic disorder closely associated with redox imbalance and excessive adipose tissue expansion, yet safe and effective natural compounds targeting early adipogenic events remain limited. Daphnetin, a naturally occurring coumarin derived from edible plants with reported antioxidant properties, has...
Xiao-Chen Shi, Ying Zhang, Yu-Tong Wang et al.· Food & Function· 0 citations
BACKGROUND AND PURPOSE
The nuclear receptor NR4A1 is a critical node in transcriptional circuits for metabolic adaptation, yet its role in adipocyte progenitor (AP) fate and proliferation is unclear. We sought to define how NR4A1 governs early adipogenesis and adipose tissue plasticity.
EXPERIMENTAL APPROACH
Doxycycl...
Wan-Ning Qiao, Cun Ku, G. V. Naveen Kumar et al.· British Journal of Pharmacol...· 0 citations
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