Chinese Herbal Medic ines

Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome by modulating the MAPK/ERK signaling pathway

Introduction Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders affecting women of reproductive age. Dendrobium officinale polysaccharides (DOP) have shown multiple pharmacological activities, but their therapeutic effects and underlying mechanisms in PCOS remain incompletely u...

Therapeutic Effect of Methanolic Extract of Nelumbo nucifera Leaves against Letrozole - Induced Polycystic Ovary Syndrome in Female Rats

Background: The most prevalent endocrine condition, Polycystic Ovary Syndrome (PCOS), is characterised by polycystic ovarian morphology, hyperandrogenism, and ovarian dysfunction. Anti-angiogenic, anti-cancer, anti-diabetic, anti-obesity, anti-inflammatory, antioxidant, anti-microbial, hepatoprotective, and anti-hyperl...

Phytochemical and Molecular Insights Into the Anti-PCOS Potential of Anchusa Strigosa: Targeting Hormones, Biochemical Markers, and WNT Genes.

Synergistic Amelioration of Endocrine Dysregulation by Vernonia amygdalina and Tamarindus indica in Letrozole and Diet-induced Polyendocrine Metabolic Ovarian Syndrome in Rats

Background: Polyendocrine metabolic ovarian syndrome (PMOS) is characterised by endocrine and reproductive disturbances involving the hypothalamic–pituitary–ovarian axis. Aim: The present study aimed to evaluate the synergistic effects of Vernonia amygdalina water extract (VAWE) and Tamarindus indica methanol extract...

Effects of Yijing decoction on diminished ovarian reserve: associations with mitochondrial function, apoptosis, and the PGC-1α/SIRT3/HIF-1α pathway

Diminished ovarian reserve (DOR) is a common reproductive disorder that severely impairs female fertility and lacks effective treatments. Protecting granulosa cells (GCs) has emerged as a promising therapeutic strategy. Yijing decoction (YJD), a classical Chinese herbal formula, exhibits clinical efficacy against D...

Efficacy of icariin in polycystic ovary syndrome: Cathepsin S as a key target revealed by computational and experimental evidence.

It is demonstrated that ICA improves PCOS by regulating CTSS in granulosa cells by regulating CTSS in granulosa cells in single-cell RNA-sequencing virtual knockout analysis.