Aug 2026· Journal of Gastrointestinal Cancer· Vol 57· 0 citations· 29 references
Medicine
TL;DR
This narrative review focuses on the practical integration of HER2 testing and HER2-directed treatment into mCRC care and proposes a clinician-oriented framework for early patient identification, treatment sequencing, and resistance assessment.
Abstract Globally, breast cancer is the most frequently diagnosed malignancy in women, with the HER2-low subtype (IHC 1+ or IHC 2+/ISH−) accounting for approximately 45%–55% of all invasive breast cancer cases. Conventional HER2-targeted therapies are ineffective for this subtype, and treatment has long relied on endoc...
Meng-Sha Yang, Xiao-Kun Ding, Peng Ye et al.· Cancer Management and Resear...· 0 citations
A narrative review summarizes the clinicopathological features of HER2-altered NSCLC, critically evaluates emerging HER2-targeted therapies, and discusses future treatment directions.
Oscar Arrieta, E. Caballé-Pérez, L. Cabrera-Miranda et al.· Critical reviews in oncology...· 0 citations
Current treatment strategies across breast cancer subtypes are summarized, emerging therapies are highlighted, and the expanding APP role is emphasized.
W. Tobin· JAAPA : official journal of...· 0 citations
Acquired resistance to osimertinib in EGFR-mutant advanced non-small cell lung cancer is inevitable, and management following progression remains an evolving clinical challenge. HER2 amplification is a recognised but underreported off-target resistance mechanism, and its optimal management is not yet established. Tra...
Mansi Sharma, Ritwika Choudhury, Abhinav Dewan et al.· Frontiers in Oncology· 0 citations
INTRODUCTION
Recently, both HER2 tyrosine kinase inhibitors (TKIs) and antibody drug conjugates (ADCs) targeting HER2 have demonstrated clinically meaningful activity and received regulatory approval for advanced HER2-mutant NSCLC, although evidence is primarily derived from single-arm trials with modest sample sizes a...
M. Li, Yu Yang Soon, Pui-Yin Au-Yeung et al.· Journal of Thoracic Oncology· 0 citations
This structured narrative review separately examines mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) and microsatellite-stable/mismatch repair-proficient (MSS/pMMR) disease and distinguish established treatments from investigational strategies and identify the remaining evidence gaps.
Alireza Tojjari, Shamim Pourbahrighesmat, Shahd Alkhazna et al.· Critical reviews in oncology...· 0 citations
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