Experimental approaches for investigating sirtuin-mediated mitochondrial function, cellular metabolism, and epigenetic regulation.

Deciphering the role of sirtuins in cancer immunoregulation through molecular cross-talk and docking-based interaction

The modulatory role of Sirtuins in FOXP3 expression and Treg differentiation is reviewed, providing insight into their contribution to tumor immunosuppression and integrating network-based analysis identified miR-34a as a central regulator and validated the miRNA-Transcription Factor-Sirtuin axis as a viable framework...

Role of sirtuin 7 (SIRT7) in hepatic physiology and pathophysiology: mechanism, prospective and therapeutic potential.

Sirtuin 7 (SIRT7) is member of the oxidized nicotinamide adenine dinucleotide (NAD+)-dependent sirtuin family of proteins that participate in the regulation of a broad spectrum of biological processes and play central roles in cellular homeostasis. Compared with other sirtuins, SIRT7 has been less studied but has emerg...

Sirtuins in mitochondrial physiology and energy homeostasis.

Lysine Acetylation as a Regulatory Mechanism in Cardiometabolic Disease: A Focus on Sirtuins

Protein lysine acetylation is a widespread post-translational modification that regulates metabolic enzyme activity and cellular function. Sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases that act as key metabolic sensors coupling cellular energy status to the regulation...

SIRT3 determines the sensitivity of cancer cells to mitochondrial targeting

The data demonstrate that SIRT3 does not play a major role in cancer cell death induced by the conventional chemotherapeutic drug cisplatin but exerts a protective role in the case of the mitochondria-targeting agent α-TOS.

A systematic evaluation of SIRT6 as a transcriptomic biomarker of aging

SIRT6 is a NAD+-dependent sirtuin that plays central roles in chromatin regulation, DNA repair, telomere maintenance, metabolic homeostasis, and inflammatory control. Although SIRT6 have long been implicated in aging because of its association with several hallmarks of aging, the available evidence remains largely cont...