The five-protein score provided incremental predictive information beyond CHA₂DS₂-VASc for post-AF stroke risk assessment and provided supportive genetic evidence for AMN, EGFR, and DCBLD2.
This large-scale proteome-wide Mendelian randomization study identified multiple plasma proteins with likely causal roles in EOS, implicating coagulation, platelet activation, extracellular matrix remodeling, and immune pathways in disease etiology.
A. Huynh, B. Gaynor, J. W. Cole et al.· medRxiv· 0 citations
Post-stroke dementia is a severe long-term stroke complication with heavy medical burdens, and early risk identification is critical. This study explored the association of muscle quality index (MQI) and plasma metabolomics with dementia among stroke survivors.
This study included 7,047 UK Biobank participan...
Zhen Tan, Shuang Li, Tian-Jiao Li et al.· Frontiers in Aging Neuroscie...· 0 citations
Plasma proteomics combined with machine learning identifies robust non-fatal MACE predictors in diabetic kidney disease patients and demonstrates favorable calibration in high-risk patients and yielded positive net clinical benefit across decision thresholds of 5% to 45%.
Li Jiang, Chieh Chien, Tian-Li Li et al.· Frontiers in Endocrinology· 0 citations
Integrated data-independent acquisition-based proteomics and WGCNA revealed a distinct plasma proteomic signature associated with prolonged SNRT in patients with PerAF, characterized by enrichment of extracellular matrix remodeling and metabolic reprogramming pathways.
Tian-Yi Lin, Tao-Jie Zhou, Yongying Lan et al.· Vessel Plus· 0 citations
Distinct metabolomic profiles were associated with incident PAD and CLI years before clinical onset, highlighting dysregulated glycemic control, impaired redox balance, and altered lipid remodeling as key underlying pathways and suggest that circulating metabolites may serve as early indicators of metabolic health rele...
E. Bansah, Xiao Hu, S. Ballew et al.· Arteriosclerosis, Thrombosis...· 0 citations
In participants with T2D and LFI, adding a metabolomic signature to SCORE2-Diabetes produced a statistically significant but moderate improvement in risk discrimination, which supports further evaluation in independent cohorts and prospective impact studies.
Mei-Li Li, Yan-Yan Shen, You-Wei Huang et al.· Frontiers in Endocrinology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.