TL;DR
This integrated computational and experimental study identifies AURKB, CDC20, KIF11, and TOP2A as key oncogenic drivers in osteosarcoma, with significant diagnostic, prognostic, and therapeutic implications.
DBF4B holds promise as both a prognostic biomarker and a novel therapeutic target for HCC after functional experiments demonstrated that silencing DBF4B markedly suppressed the proliferative and migratory capabilities of HCC cells.
Functional data link LINC02163 expression to HCC cell growth, PI3K/AKT pathway activity, and changes in stemness-related markers, although the underlying mechanism remains to be established.
The expression level of STAT1 is positively correlated with the degree of lymph node metastasis in ESCC clinical samples, and STAT1 serves as a biomarker for lymph node metastasis in ESCC.
INTRODUCTION Metastatic spread remains the leading cause of death in Nasopharyngeal Carcinoma (NPC); however, the role of mitochondrial homeostasis in this process remains largely unclear. OBJECTIVE This study aims to identify key genes associated with mitochondrial homeostasis and NPC metastasis, and to further expl...
A seven-gene immune-related prognostic signature that, combined with clinicopathological parameters, provides a robust tool for individualized survival prediction and may guide precision management in CRC patients is developed and validated.
Elevated TPD52 expression was associated with longer overall survival in specific subgroups, including the basal-like subtype, invasive lobular carcinoma, and N0/N1 stages, and a random forest-based diagnostic model demonstrated high accuracy across multiple datasets.
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