TL;DR
Automated FiO2 control consistently improves oxygen targeting, but current randomized evidence does not show clear benefit for major neonatal outcomes.
Background Closed-loop oxygen control (CLOC) systems improve accuracy of oxygen delivery compared with standard manual oxygen adjustment. Determination of their efficacy in delivering oxygen noninvasively to adults, using different delivery methods and across different hospital locations, would enhance clinical practic...
OBJECTIVE To compare rule-based non-fuzzy algorithm (Predictive Intelligent Control of Oxygenation (PRICO)) with adaptive algorithm (Closed-loop Inspired Oxygen (CLiO2)) for automated oxygen control in mechanically ventilated neonates. DESIGN Open label, randomised, crossover trial. SETTING Level III neonatal inten...
Close-loop insulin delivery may improve glycaemic process measures, but larger pragmatic trials are needed to establish clinical benefits, safety, and implementation feasibility.
Guidelines recommend titrating oxygen to maintain oxygen saturation (SpO2) within a target range. Clinical studies report that manual oxygen titration processes are inaccurate, exposing patients to risks associated with both inadequate and excessive oxygen. The studies presented in this thesis aim to investigate the ef...
Background: Supplemental oxygen is common in paediatric care, but target saturation is not standardised and excessive exposure has been associated with organ dysfunction and death. Objective: To compare conservative and liberal oxygenation targets for mortality, serious adverse events, length of stay, and treatment fa...
Continuous endotracheal tube cuff pressure control is intended to maintain cuff pressure within the recommended range, reduce microaspiration, and prevent ventilator-associated pneumonia (VAP). However, randomized trials have produced apparently inconsistent findings. The clinical question is therefore not only whe...
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