Improved understanding of the integrated landscape of the RCD network may facilitate the discovery of novel biomarkers and support the development of innovative therapies to restore immune tolerance and control chronic inflammatory damage in autoimmune diseases.
Autoimmune diseases are a category of chronic disorders in which the body's immune system fails to distinguish between self-antigens and foreign substances, leading to attacks on its own tissues and subsequent damage. B cells play critical roles in humoral immunity, including antibody production, antigen presentation,...
Autoimmune diseases arise from the amplification of natural autoreactive immune clones in genetically susceptible individuals under the influence of environmental triggers, epigenetic modifications, and hormonal factors. They comprise a broad and heterogeneous group of disorders characterized by immune-mediated tissue...
H. Moutsopoulos· Current Opinion in Immunolog...· 0 citations
Hypertension is a leading cause of global cardiovascular morbidity and mortality, yet its primary etiology remains poorly defined. Accumulating evidence increasingly positions inflammation as a key determinant of disease progression, with both innate and adaptive immune mechanisms playing central roles. Under physiolog...
Omar Tluli, Alaa Abdelhamid, Yaman Al-Haneedi et al.· Frontiers in Pharmacology· 1 citation
Hyperuricaemia (HUA) is a metabolic disorder that can not only predispose patients to gout but also be associated with renal, cardiovascular, and metabolic diseases. Recent evidence has designated programmed cell death (PCD) as a central event that drives tissue injury and inflammation in HUA. Raised soluble urate and...
Heng Sai, Hao-Jun Shen, Jing Fu et al.· Frontiers in Cell and Develo...· 0 citations
This review provides a comprehensive overview of the cellular and molecular mechanisms underlying antibody-based therapies, summarizes major therapeutic target classes across autoimmune diseases, and examines their clinical and mechanistic limitations.
N. Mahroum· International Journal of Mol...· 0 citations
Inflammation is a fundamental biological response required for host defense, tissue repair, and maintenance of homeostasis. Although acute inflammation is protective and self-limiting, persistent or dysregulated inflammation contributes to the initiation and progression of many chronic diseases. This review aims to exa...
Karthika Padmavathy, M. Beevi, Ajab Singh Choudhary et al.· Genetics and Molecular Resea...· 0 citations
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