Aug 2026· Journal of Neuroimmune Pharmacology· Vol 21· 0 citations· 159 references
Medicine
TL;DR
This review highlights the molecular and pathological mechanisms of cGAS-STING signaling in a broader aspect of neurological disorders and appraises the novel therapeutics already under development to inhibit this pathway to regulate neuroinflammation and enhance neurological outcomes.
This review critically evaluates recent advances in NIM-based strategies for AD and PD, including intrinsically therapeutic nanomaterials, targeted delivery systems, and precision gene-regulatory platforms and discusses AI-driven nanomedicine optimization and advanced human-relevant models, including brain-on-a-chip sy...
Mohammed A. Abdel-Rasol· InflammoPharmacology· 0 citations
Aberrant activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has been increasingly recognized as a key driver of autoimmune and inflammatory diseases. In recent years, accumulating evidence has highlighted the close association between cGAS-STING signaling and the pathogenesi...
Dongxiao Cui, Huanhuan Zhang, Yanan Nan et al.· Pharmacological Research· 0 citations
As a pivotal module of the innate immune system, the cGAS-STING signaling pathway is responsible for sensing cytosolic DNA and triggering inflammatory reactions, and it exerts a vital function in the pathological progression of hemorrhagic stroke.This review synthesizes current evidence on the involvement of cGAS-STING...
The cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS-STING) pathway is a central component of innate immunity, mediating host defense against pathogens, antitumor responses, and inflammation. Aberrant activation of this pathway is implicated in a spectrum of diseases, including autoimmune disorders, chronic...
Yi Yang, Yi-Heng Sun, Yu-Xia Cheng et al.· Chinese Medicine· 0 citations
This review systematically investigates the distinct functional states and biological behaviors of the cGAS-STING pathway under a variety of disease conditions to provide comprehensive theoretical references and research directions for follow-up basic mechanistic studies and clinical transformation of cGAS-STING target...
Minjue Shan, Yan Liao, Zi-You Lin et al.· Apoptosis· 0 citations
BACKGROUND
Neurodegenerative diseases may continue to progress even when a pathogenic protein aggregate is reduced, suggesting that downstream inflammatory and genotoxic circuits can become partly autonomous. This narrative review examines cGAS-STING as a context-dependent regulator of DNA-stress responses in the agein...
Chun-Fang Zhang, Zhang-Qin Yang· Brain Research Bulletin· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
