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Autoimmune disease patients with comorbid cancer exhibit prominent immunometabolic crosstalk.

Xu Jiang Yangzhige He Nai-Xin Liang Xiang-Yi Shen Ziyue Zhou Dan Yang Jiana Chen Jiaqi Xu Mengyuan Wang Yiyi Gong X. Si Li Zhang Li-Dan Zhao Yunyun Fei Feng-Chun Zhang Meng-Tao Li Hua-Xia Yang
Aug 2026 · Science China Life Sciences · 0 citations · 53 references
Medicine

TL;DR

Together, these findings define an internally consistent immunometabolic pattern associated with cancer comorbidities in patients with AIDs and nominate amino acid metabolism and CXCL9/Galectin-9-centered immune signaling as candidates for mechanistic investigation and biomarker development, while underscoring the need for validation in larger, longitudinal, and disease-specific cohorts.

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