This study identified tyrosine phosphoprotein A (TypA) as a repressor that restricts expression of the T3SS in P. aeruginosa and reveals a novel molecular mechanism by which P. aeruginosa regulates T3SS.
Li-Wen Yin, Yi-Ming Li, Xue-Tao Gong et al.· Microorganisms· 0 citations
Background:
Zoonotic diseases are illnesses that humans can contract from animals and vice versa. Pseudomonas aeruginosa is an opportunistic organism that makes treating infections challenging, particularly in individuals with underlying medical conditions and those with impaired immune systems. The increasing number o...
Abdul-Nafea Hassan, Ibtisam Q. Abdulkareem· Open Veterinary Journal· 0 citations
It is demonstrated that R-pyocins can be leveraged not merely as conventional biocides, but as precise selective forces to drive an evolutionary “checkmate” strategy, establishing a framework for using R-pyocins to force predictable evolutionary trade-offs, driving the reversion of multidrug resistance to an attenuated...
Isaac Estrada, Davina Campbell, G. Welch et al.· bioRxiv· 0 citations
Genetic analysis of the SAUSA300_1739 to SAUSA300_1744 operon across several Staphylococcus aureus strains indicate that the operon is highly conserved, highlighting its importance for virulence.
Alex Zilinskas, H. M. Ni, Zoe Netter et al.· bioRxiv· 0 citations
Overall, it is demonstrated the transcriptomic basis of MexT as a phenotypic switch in PAO1 and implicated antibiotic resistance as a cause of downstream changes in mexT in P. aeruginosa, confirming that PAO1 is a very different organism compared to most isolates.
Annapaula Correia, Emma J. Manners, Benjamin A. Evans et al.· bioRxiv· 0 citations
It is demonstrated that Spongosorites sp-derived bisindole alkaloid (R)-6’-debromohamacanthin B (RDB) exerts dual bacterium-directed and host-directed activities, simultaneously attenuating virulence and biofilm formation while reinforcing host defense and controlling pathological inflammation.