Cross-Modal Brain Network Disruptions in Schizophrenia: Insights from Multiplex Modeling and Transcriptomic Associations.

Prevalent and characteristic alterations in blood-brain transcriptomic-functional imaging coupling in schizophrenia.

Findings reveal distinct, reproducible dysregulation of peripheral-central functional coupling in SCZ, offering a multi-scale framework for understanding its pathophysiology and highlighting the potential of trans-scale features as candidate biomarkers for diagnosis and mechanistic insight.

754. Developmental Reorganization of Network Functional Connectivity Abnormalities and Molecular Signatures in Attention-Deficit/Hyperactivity Disorder

It is demonstrated that ADHD is characterized by developmentally FC alterations, and a key reversal in DMN-VAN connectivity between child and adult patients is identified, supporting models of delayed maturation and compensatory reorganization.

Disrupted cortical hierarchy and delayed connectome-based propagation in the functional connectome of schizophrenia

Abstract Background Schizophrenia is associated with widespread abnormalities in large-scale brain organization; however, the mechanisms linking altered cortical hierarchy to disrupted neural communication and clinical symptoms remain unclear. By integrating functional connectivity gradient analysis and stepwise functi...

Altered cortical-subcortical structural connectivity underlying symptom dimensions in schizophrenia

Linking Gene Sequences to Brain Connectivity Alterations in Schizophrenia

An intelligent computational system that integrates genomic data with functional magnetic resonance imaging to establish meaningful correlations between genetic variations in key schizophrenia-associated genes and altered brain connectivity patterns to deliver a comprehensive gene-brain analysis system capable of predi...

Localizing the structural and functional alteration networks associated with borderline personality disorder.

BACKGROUND Although structural and functional alterations in borderline personality disorder (BPD) have been widely reported in neuroimaging studies, the findings remain heterogeneous. Emerging consensus suggests that these distributed alterations may converge on a common pathological network associated with BPD, provi...