TL;DR
While the low frequency rebound activity hinders relay of excitatory cortical inputs by the TCR neuron, high frequency stimulation with parameter settings corresponding to this specific window restores the relay functionality.
Improved movement initiation and increased impulsivity under stimulation of the subthalamic nucleus are linked to a shared anatomical and functional substrate, namely the subthalamic nucleus-supplementary motor cortex loop supporting automatic response inhibition.
The stimulation-induced decreases in phase-amplitude coupling were correlated with real-time improvement in bradykinesia and predicted by clinical factors, and could be predicted in task-specific pathways consisting of the primary motor cortex and the dorsal premotor cortex.
The findings suggest that quasi-evoked inhibition is a potential biomarker of tremor reduction by means of network inhibition, and the more posterior regions of the Vim may allow for better recruitment of inhibition, which may be useful for closed-loop stimulation design.
Deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR) has been explored to treat gait disturbances. However, clinical outcomes of MLR-DBS have been disappointing overall, with only modest benefits in some individuals and unwanted effects, including anxiety, reported in others. Preclinical studies in...
Deep brain stimulation (DBS) is an established intervention for Parkinson’s disease (PD), whereas the network-level effects of prescribed periodic visual input implemented with 10 Hz base pulses remain uncertain. We developed a conductance-based cortico-basal ganglia-thalamic (CBT) model comprising 11 Hodg...
Objective Visual attention deficits are common but under-recognized in Parkinson’s disease (PD), and we investigate whether theta-frequency (5 Hz) STN-DBS differentially modulates visual attention compared with high-frequency (130 Hz) stimulation in PD patients. Methods Thirty-nine PD patients with bilateral STN-DBS pe...
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